In the realm of fine chemicals and organic synthesis, the purity and reliable production of intermediates are paramount. Valerophenone (CAS 1009-14-9) stands out as a versatile aromatic ketone with a significant role in various industries, including pharmaceuticals, agrochemicals, and fragrances. For procurement managers and research scientists seeking high-quality organic intermediates, understanding the synthesis pathways of Valerophenone is crucial. This article delves into the common methods used to manufacture Valerophenone, emphasizing aspects relevant to sourcing from a reputable manufacturer in China.

One of the most prevalent and industrially significant methods for synthesizing Valerophenone is the Friedel-Crafts acylation. This classic organic reaction involves the reaction of benzene with valeryl chloride (pentanoyl chloride) in the presence of a Lewis acid catalyst, such as aluminum chloride (AlCl3) or ferric chloride (FeCl3). The benzene ring acts as a nucleophile, attacking the activated acyl chloride. This process is highly effective for introducing the pentanoyl group onto the benzene ring, yielding Valerophenone. For businesses looking to buy Valerophenone, understanding that reliable suppliers often utilize optimized Friedel-Crafts acylation ensures product quality and consistency.

Another notable synthesis route for Valerophenone involves the Grignard reaction. This method typically uses a phenyl Grignard reagent reacting with pentanoyl chloride or ester. While effective, managing Grignard reagents requires careful control of anhydrous conditions and specific handling procedures, which are well-understood by experienced chemical manufacturers. The choice of synthesis method often depends on desired purity levels, cost-effectiveness, and available raw materials. Sourcing from a supplier of CAS 1009-14-9 means gaining access to products manufactured under controlled conditions, tailored for specific applications.

The purity of Valerophenone is critical, especially when it's used as a pharmaceutical intermediate or a component in sensitive formulations. Manufacturers often implement rigorous purification steps, such as distillation, to achieve the desired assay, typically ≥99% purity. When inquiring about Valerophenone price, it's essential to consider the purity specifications and the manufacturing process employed by the organic intermediate supplier. A higher purity grade, often termed 'laboratory grade' or 'synthesis grade', commands a different price point than industrial grades.

For companies actively searching to purchase Valerophenone, partnering with a reputable Valerophenone manufacturer like NINGBO INNO PHARMCHEM ensures access to technical data, certificates of analysis (COA), and reliable shipping. We pride ourselves on delivering consistent quality and supporting our clients' research and production needs with timely deliveries. Exploring options for high purity Valerophenone for sale is a strategic step for optimizing synthesis outcomes and product performance.

In conclusion, the synthesis of Valerophenone involves well-established organic chemistry principles, primarily Friedel-Crafts acylation and Grignard reactions. By understanding these processes and prioritizing suppliers who offer high purity and consistent quality, businesses can confidently procure this vital organic intermediate for their diverse chemical applications. When you need to buy Valerophenone in China, focusing on experienced manufacturers guarantees the reliability and performance required for your projects.