The pyridine scaffold is a fundamental motif in organic chemistry, appearing in a vast array of biologically active molecules and functional materials. Among the many substituted pyridines, 2-Amino-4-chloropyridine (CAS 19798-80-2) holds particular significance due to its versatile chemical properties and its utility as a precursor in numerous synthesis pathways. Understanding its core characteristics is key for chemists and manufacturers working with this important intermediate.

Chemically, 2-Amino-4-chloropyridine is a white to light yellow crystalline powder. Its molecular formula is C5H5ClN2, with a molecular weight of approximately 128.56 g/mol. The compound exhibits a melting point typically between 126-127°C, indicating its solid state at room temperature. The presence of the electron-withdrawing chlorine atom and the electron-donating amino group on the pyridine ring influences its reactivity. The pyridine nitrogen atom provides a site for protonation, with a pKa of around 5.72, making it a weakly basic compound. Its solubility in common solvents like ethanol and water further adds to its handling convenience in laboratory and industrial settings.

The synthesis of 2-Amino-4-chloropyridine often involves multi-step chemical processes. A common route starts from pyridine derivatives, where specific functional groups are introduced or modified through reactions like halogenation, amination, and cyclization. For instance, starting from precursors like 4-chloropicolinic acid derivatives, through stages involving hydrazide formation and subsequent cyclization or reduction, the desired 2-amino-4-chloropyridine can be obtained. The optimization of these synthesis routes is critical for achieving high yields and purity, ensuring the cost-effectiveness of the final product.

The primary applications of 2-Amino-4-chloropyridine stem from its role as a key intermediate. In pharmaceutical synthesis, it is vital for creating antiviral drugs, kinase inhibitors used in cancer therapy, and various other therapeutic agents. Its ability to undergo cross-coupling reactions and nucleophilic substitutions allows for the efficient construction of complex drug molecules. In the agrochemical sector, it serves as a precursor for pesticides and herbicides, contributing to advancements in crop protection. The ability to order 2-Amino-4-chloropyridine from reputable manufacturers like NINGBO INNO PHARMCHEM CO.,LTD. is crucial for the continuity of these critical manufacturing processes.

NINGBO INNO PHARMCHEM CO.,LTD. is a leading supplier of 2-Amino-4-chloropyridine, committed to providing high-quality material that meets the demanding specifications of the chemical industry. Their expertise in synthesis and quality control ensures that clients receive a reliable product for their diverse applications. Whether for pharmaceutical R&D, agrochemical production, or fine chemical synthesis, understanding the chemical properties and sourcing from trusted providers like NINGBO INNO PHARMCHEM CO.,LTD. is paramount.

In summary, 2-Amino-4-chloropyridine is a fundamental heterocyclic compound with well-defined chemical properties and established synthesis routes. Its significance as a versatile intermediate in pharmaceuticals, agrochemicals, and other fine chemical applications makes it an indispensable component in modern chemical synthesis.