Organic synthesis is the cornerstone of modern chemistry, enabling the creation of novel molecules with applications ranging from pharmaceuticals to advanced materials. Within this field, heterocyclic compounds, particularly pyridine derivatives, hold significant importance due to their presence in many biologically active molecules. This article explores the utility of 4-Iodo-2-methoxypyridine-3-carboxaldehyde (CAS: 158669-26-2) as a versatile building block in organic synthesis, detailing its properties and applications, and guiding researchers on how to efficiently buy this compound.

Understanding the Chemical Profile of 4-Iodo-2-methoxypyridine-3-carboxaldehyde

4-Iodo-2-methoxypyridine-3-carboxaldehyde is a functionalized pyridine derivative characterized by an iodine atom at the 4-position, a methoxy group at the 2-position, and a carboxaldehyde group at the 3-position. This specific arrangement of functional groups imbues the molecule with diverse reactivity, making it a valuable starting material for various synthetic transformations. The presence of the iodine atom, for instance, readily participates in cross-coupling reactions such as Suzuki, Sonogashira, and Buchwald-Hartwig couplings, allowing for the introduction of various carbon-based substituents. The aldehyde group is amenable to nucleophilic additions, reductions, and oxidations, further expanding its synthetic utility. Its description as a light yellow to yellow solid with a purity of 97% min. signifies its suitability for demanding synthetic protocols.

Key Applications in Advanced Synthesis

The primary application of 4-Iodo-2-methoxypyridine-3-carboxaldehyde lies in its role as an intermediate in the pharmaceutical industry. It is specifically noted for its use in synthesizing insulin-like growth factor 1-receptor (IGF-1R) inhibitors, compounds that are actively researched for their potential anti-tumor activities. Beyond this specific application, its versatile reactivity makes it a sought-after reagent for researchers exploring the synthesis of other complex heterocyclic systems, novel agrochemicals, and specialty fine chemicals. Its ability to be functionalized at multiple points makes it an indispensable tool for creating structural diversity in drug discovery programs.

Sourcing Strategy: Finding a Reliable Manufacturer

For chemists and procurement specialists, sourcing high-quality 4-Iodo-2-methoxypyridine-3-carboxaldehyde is crucial for successful research outcomes. When looking for a supplier, consider their expertise in producing heterocyclic compounds and their commitment to quality control. Partnering with a dedicated manufacturer, particularly one based in China, often provides access to competitive pricing and a reliable supply chain. Thoroughly vetting potential suppliers to ensure they meet your purity and delivery requirements is a vital step in securing this essential organic synthesis reagent.

We are a dedicated manufacturer and supplier of 4-Iodo-2-methoxypyridine-3-carboxaldehyde, offering high-purity products for your organic synthesis needs. Leverage our expertise and commitment to quality to accelerate your research. Contact us today for a quote and to learn more about our product offerings and reliable sourcing capabilities.