1-Methyl-2-pyrrolidineethanol (CAS 67004-64-2) stands out as a remarkably versatile chemical compound, finding critical applications in both the pharmaceutical industry and emerging fields of material science. Its unique structural features, including a chiral center and a combination of amine and alcohol functionalities, make it an invaluable intermediate and building block for a wide array of advanced applications. This article explores its key attributes, synthesis, and diverse roles, highlighting why NINGBO INNO PHARMCHEM CO.,LTD. is a trusted partner for sourcing this essential chemical.

Chemical Profile and Synthesis
This compound is a colorless to clear yellow or brownish liquid with a molecular formula of C₇H₁₅NO and a molecular weight of 129.20 g/mol. Its chemical structure features a 1-methylpyrrolidine ring substituted at the 2-position with a 2-hydroxyethyl group. The synthesis of 1-Methyl-2-pyrrolidineethanol can be achieved through various routes, with modern methods focusing on efficiency, safety, and cost-effectiveness. A key industrial synthesis involves the two-stage reduction of methyl (2E/Z)-2-(1-methylpyrrolidin-2-ylidene)acetate using sodium borohydride, a process that offers significant advantages in terms of operational safety and cost compared to older, high-pressure catalytic hydrogenation methods. As a reliable manufacturer in China, NINGBO INNO PHARMCHEM CO.,LTD. employs optimized synthesis techniques to ensure high purity and consistent product quality.

Applications in Pharmaceutical Development
In the pharmaceutical sector, 1-Methyl-2-pyrrolidineethanol is highly valued as a pharmaceutical intermediate. It serves as a crucial chiral building block in the synthesis of numerous APIs. Its specific stereochemistry is vital for drugs where enantiomeric purity dictates pharmacological activity and safety. It is notably used in the synthesis of antihistamines like Clemastine and has relevance in the production pathways for other therapeutic agents. The demand for high-purity 1-Methyl-2-pyrrolidineethanol from pharmaceutical companies underscores its importance in drug discovery and manufacturing.

Emerging Roles in Material Science and Catalysis
Beyond pharmaceuticals, the unique properties of 1-Methyl-2-pyrrolidineethanol are opening doors in material science. Its structural similarity to N-methyl-2-pyrrolidone (NMP), a widely used solvent in battery manufacturing and polymer processing, suggests potential applications. Researchers are exploring derivatives as components in electrolyte solutions for lithium-ion batteries to enhance stability and performance, or as specialty solvents. Furthermore, its chiral derivatives are of significant interest in asymmetric catalysis, serving as ligands for metal catalysts to facilitate the stereoselective synthesis of valuable chiral compounds. These applications highlight its growing importance in advanced technological sectors.

Quality and Reliability from NINGBO INNO PHARMCHEM CO.,LTD.
As a leading manufacturer and supplier, NINGBO INNO PHARMCHEM CO.,LTD. is committed to delivering 1-Methyl-2-pyrrolidineethanol that meets the highest industry standards. Our robust quality control systems, advanced manufacturing facilities, and dependable supply chain ensure that our clients receive a consistent, high-purity product. We understand the critical role this intermediate plays in your research and production processes, and we strive to be your trusted partner. Whether for pharmaceutical synthesis, material science research, or other chemical applications, we invite you to inquire about pricing, samples, and bulk orders to discover how we can support your innovative projects.