Organic synthesis is the art and science of constructing complex molecules from simpler precursors. At the heart of this discipline lies a toolkit of versatile building blocks, each offering unique reactivity and structural potential. Among these indispensable compounds, 4-Bromo-1-indanone (CAS 15115-60-3) has carved out a significant niche due to its inherent chemical properties and wide-ranging applications. As a specialized manufacturer and supplier of fine chemicals, we are proud to offer this compound, understanding its profound value to synthetic chemists worldwide.

The fundamental utility of 4-Bromo-1-indanone in organic synthesis can be attributed to its structure: an indanone ring system functionalized with a bromine atom at the 4-position. This bromine atom serves as an excellent leaving group, making the molecule highly amenable to nucleophilic substitution and, more importantly, to a variety of metal-catalyzed cross-coupling reactions. These reactions are the cornerstone of modern organic synthesis, enabling the formation of robust carbon-carbon and carbon-heteroatom bonds with remarkable efficiency and selectivity.

One of the most prominent applications of 4-Bromo-1-indanone lies in its participation in palladium-catalyzed cross-coupling reactions. The Suzuki-Miyaura coupling, for instance, allows for the facile reaction of the aryl bromide with organoboron compounds (boronic acids or esters) to form new C-C bonds. This is incredibly useful for attaching various aryl or vinyl groups to the indanone scaffold, thereby creating diverse and complex polycyclic aromatic systems. Similarly, the Heck reaction enables the coupling with alkenes, extending carbon chains and introducing unsaturation. These reactions are pivotal for assembling the complex structures found in many pharmaceutical agents and advanced materials.

The indanone core itself also offers opportunities for further functionalization. The carbonyl group can undergo typical ketone reactions, such as reductions, nucleophilic additions, and Wittig reactions, providing additional avenues for molecular elaboration. This dual reactivity – at the bromine atom and the carbonyl center – makes 4-Bromo-1-indanone a truly multi-talented synthetic intermediate. Researchers looking to buy this compound often do so because of its potential to unlock multiple synthetic pathways from a single starting material.

Beyond these general synthetic strategies, 4-Bromo-1-indanone is a known precursor in the synthesis of biologically active molecules. Its ability to be incorporated into larger structures that mimic or interact with biological targets makes it invaluable in medicinal chemistry. For instance, it is a key intermediate in the synthesis of certain TRPV1 antagonists, explored for their analgesic properties, and in the development of kinase inhibitors with potential anti-cancer applications. The demand from the pharmaceutical sector for high-purity intermediates like ours underscores its importance.

As a manufacturer, we ensure that our 4-Bromo-1-indanone is produced to high standards of purity, typically exceeding 97% by GC. This is critical for the success of delicate coupling reactions and for meeting the exacting requirements of pharmaceutical synthesis. We encourage researchers and chemical companies to consider us as their reliable supplier, offering not only the product itself but also the assurance of quality that is essential for pushing the boundaries of organic synthesis. For those seeking to buy this versatile building block, contacting us for a quote is the first step towards unlocking new molecular possibilities.