For R&D chemists and formulation scientists, the selection of the right chemical intermediates is pivotal for the success of their projects. 4-Bromofluorobenzene (CAS: 460-00-4) stands out as a particularly versatile and valuable compound in the realm of modern organic synthesis. This aromatic halide, with its dual halogen substituents, offers a unique reactivity profile that makes it indispensable for creating sophisticated molecules used in a myriad of applications, from life sciences to materials development.

Why 4-Bromofluorobenzene? A Chemist's Perspective

The chemical structure of 4-Bromofluorobenzene, C6H4BrF, combines the electron-withdrawing properties of fluorine with the leaving group capability of bromine on a stable benzene core. This arrangement allows it to participate effectively in a wide array of organic transformations. Its physical state as a colorless liquid and a high boiling point (around 150°C) make it manageable in laboratory settings. Crucially, its availability with purity levels of 99.0% and above ensures reliable and reproducible results, a critical factor for research chemists aiming to buy and utilize chemical compounds.

Key Reactions and Applications

The true value of 4-Bromofluorobenzene lies in its participation in key synthetic reactions:

  • Cross-Coupling Reactions: It is a prime substrate for palladium-catalyzed cross-coupling reactions, such as Suzuki-Miyaura, Heck, and Sonogashira couplings. These reactions are foundational for forming new carbon-carbon bonds, enabling the construction of complex molecular architectures. Scientists often search for a reliable supplier of 4-Bromofluorobenzene to facilitate these advanced syntheses.
  • Grignard Reagent Formation: Reaction with magnesium forms the Grignard reagent, 4-fluorophenylmagnesium bromide. This organometallic compound is a powerful nucleophile, widely used to introduce the 4-fluorophenyl moiety into organic molecules, which is a common structural feature in many pharmaceuticals and agrochemicals.
  • Nucleophilic Aromatic Substitution: While less common due to the presence of the bromine atom, the fluorine atom can also undergo substitution reactions under specific conditions, further expanding its synthetic utility.

These reactivities translate into diverse applications. In the pharmaceutical industry, 4-Bromofluorobenzene is a key intermediate for synthesizing compounds with specific biological activities. Similarly, in agrochemical development, it contributes to the creation of effective crop protection agents. Its role in research laboratories is equally significant, where it aids in the discovery of new chemical entities and the optimization of synthetic routes. For professionals seeking to purchase this compound, understanding its broad application scope is vital.

Sourcing Excellence from Leading Manufacturers

As a dedicated supplier and manufacturer, we pride ourselves on providing 4-Bromofluorobenzene that meets the highest standards of purity and consistency. Our commitment to quality ensures that researchers and industrial chemists can rely on our product for their most demanding synthetic challenges. We understand the market's need for competitive pricing and efficient delivery. Therefore, we encourage you to connect with us for your procurement needs, whether for laboratory research or commercial-scale production. Buying 4-Bromofluorobenzene from a trusted source like us means investing in the reliability and success of your chemical endeavors.