In the realm of chemical synthesis, the availability of versatile and high-quality building blocks is paramount for innovation and efficiency. 4-(Trifluoromethylthio)benzonitrile, identified by its CAS number 332-26-3, has emerged as a compound of significant interest due to its broad utility across multiple chemical sectors, including pharmaceuticals, agrochemicals, and advanced materials. For R&D scientists and procurement managers, understanding its properties and how to buy it effectively is key.

Understanding the Chemical Structure and Properties

4-(Trifluoromethylthio)benzonitrile is characterized by a nitrile group (-CN) and a trifluoromethylthio group (-SCF3) attached to a benzene ring. This combination imparts unique reactivity and electronic properties, making it an excellent scaffold for further chemical transformations. The presence of the electron-withdrawing trifluoromethylthio group influences the reactivity of the nitrile and the aromatic ring, opening up various synthetic pathways. Its moderate melting point (39-43 °C) and boiling point (89-90 °C at 10 Torr) also contribute to its ease of handling in laboratory and industrial settings.

Key Applications Across Industries

The versatility of 4-(trifluoromethylthio)benzonitrile is reflected in its diverse applications:

  • Organic Synthesis: It serves as a fundamental building block for constructing more complex organic molecules. The nitrile group can be hydrolyzed, reduced, or reacted in cycloaddition reactions, while the aromatic ring can undergo electrophilic or nucleophilic aromatic substitution.
  • Pharmaceuticals: As a crucial intermediate, it is used in the synthesis of various APIs, contributing to the development of new drugs with improved pharmacokinetic and pharmacodynamic properties.
  • Agrochemicals: It is employed in the creation of new herbicides, insecticides, and fungicides, where the trifluoromethylthio group can enhance biological activity and stability.
  • Material Science: Potential applications exist in the development of specialty polymers, liquid crystals, or functional dyes where its unique electronic properties can be exploited.

When seeking to buy this compound, sourcing from reliable manufacturers, particularly those in China known for their chemical expertise, is a common strategy to ensure both quality and competitive pricing.

Procurement Tips for Buyers

For professionals looking to purchase 4-(trifluoromethylthio)benzonitrile (CAS 332-26-3), consider the following:

  1. Identify Reputable Suppliers: Look for manufacturers with a strong commitment to quality control and consistent product specifications.
  2. Request Detailed Information: Obtain Certificates of Analysis (CoA) and Material Safety Data Sheets (MSDS) to understand the product's properties and handling requirements.
  3. Inquire About Bulk Pricing: If your needs extend beyond laboratory quantities, negotiate pricing for larger orders to maximize cost-effectiveness.
  4. Verify Lead Times: Confirm delivery schedules to ensure they align with your project timelines.

By understanding the chemical properties and market availability of 4-(trifluoromethylthio)benzonitrile, businesses can leverage this valuable intermediate to drive innovation and achieve their synthesis goals. It remains a key component for researchers and manufacturers alike.