In the realm of chemical synthesis, access to versatile and reactive intermediates is key to innovation. Dimethyl 5-ethynylisophthalate (CAS: 313648-56-5) stands out as a compound offering significant utility, particularly for those in the pharmaceutical and fine chemical industries looking to buy a reliable building block. Its unique combination of functional groups—an ethynyl moiety and two ester groups on an aromatic ring—renders it invaluable for constructing complex molecular architectures.

The Chemical Powerhouse: Understanding its Structure and Reactivity

The core of Dimethyl 5-ethynylisophthalate's utility lies in its structure. The ethynyl group, a terminal alkyne, is a highly reactive functional group. It readily participates in a diverse range of chemical transformations, including but not limited to:

  • Click Chemistry (Huisgen Cycloaddition): Reaction with azides to form triazoles, a widely used reaction for conjugation and bioconjugation.
  • Sonogashira Coupling: Palladium-catalyzed coupling with aryl or vinyl halides to form extended conjugated systems.
  • Metal-Catalyzed Reactions: Participation in various other coupling and addition reactions, expanding its synthetic scope.

Furthermore, the two methyl ester groups provide additional handles for chemical modification. They can be hydrolyzed to carboxylic acids, esterified with different alcohols, or reduced to hydroxymethyl groups. This multifaceted reactivity allows chemists to design intricate synthesis pathways and incorporate specific functionalities into target molecules.

Applications Driving Market Demand

The primary driver for the demand for Dimethyl 5-ethynylisophthalate is its role as a pharmaceutical intermediate. It serves as a crucial component in the synthesis of various APIs, where its functional groups are strategically manipulated to build complex drug molecules. Researchers in medicinal chemistry leverage its reactivity to create novel drug candidates with enhanced efficacy and specificity.

Beyond pharmaceuticals, its applications extend to materials science. The ethynyl group can be utilized for polymerization or cross-linking reactions, leading to the development of specialty polymers, advanced coatings, or components for organic electronic devices. The aromatic core provides structural rigidity, while the functional groups allow for tailored properties in the resulting materials.

Procurement Best Practices

For organizations looking to buy Dimethyl 5-ethynylisophthalate, it is essential to partner with reliable manufacturers and suppliers. These partners typically offer high-purity products (e.g., 98%) with detailed Certificates of Analysis (CoA). When making a purchase decision, consider factors such as:

  • Supplier Reputation: Look for manufacturers with a proven track record in producing and supplying fine chemicals.
  • Quality Assurance: Verify that the supplier adheres to strict quality control protocols.
  • Pricing and Volume: Obtain quotes for your required quantities, as pricing often scales with volume.
  • Logistics and Delivery: Ensure the supplier can handle your shipping and delivery requirements efficiently.

By carefully selecting your supplier and understanding the versatile chemical potential of Dimethyl 5-ethynylisophthalate, you can effectively utilize this intermediate to drive innovation in your research and manufacturing endeavors.