The Versatility of Ethyl 3-chloro-4-fluorobenzoate in Organic Synthesis
Ethyl 3-chloro-4-fluorobenzoate (CAS: 137521-81-4) is a cornerstone in modern organic synthesis, prized for its specific chemical structure that enables a wide array of synthetic transformations. As a vital intermediate, its demand is driven by the pharmaceutical and agrochemical sectors, where innovative compound development is continuous. For R&D scientists and formulators, understanding its versatile applications is key to unlocking new product potential.
The molecular structure of Ethyl 3-chloro-4-fluorobenzoate, featuring a chlorine atom, a fluorine atom, and an ester group on a benzene ring, provides multiple reactive sites. The fluorine atom, in particular, often enhances the metabolic stability and lipophilicity of resulting molecules, making it highly sought after in drug discovery. The ester group can undergo hydrolysis, reduction, or transesterification, while the aromatic ring can participate in electrophilic aromatic substitution reactions, albeit influenced by the existing substituents.
This compound serves as a crucial precursor in the synthesis of various biologically active molecules. In the pharmaceutical industry, it's used to build complex heterocyclic systems or introduce specific fluorinated aromatic motifs into drug candidates targeting a range of diseases. Similarly, in agrochemicals, its incorporation can lead to more potent and environmentally stable pesticides or herbicides. Researchers looking to buy this intermediate for their projects will find it a reliable starting point for creating novel compounds.
As a trusted manufacturer and supplier of this essential intermediate, NINGBO INNO PHARMCHEM CO.,LTD. ensures consistent quality and availability. Our expertise allows us to provide high-purity Ethyl 3-chloro-4-fluorobenzoate, supporting your innovation efforts. Whether you are exploring new synthetic routes or scaling up production, our commitment to quality and service makes us an ideal partner. For those seeking to purchase this versatile chemical, direct inquiry for quotes and samples is recommended to explore bulk purchase options and discuss specific application requirements.
Perspectives & Insights
Data Seeker X
“The molecular structure of Ethyl 3-chloro-4-fluorobenzoate, featuring a chlorine atom, a fluorine atom, and an ester group on a benzene ring, provides multiple reactive sites.”
Chem Reader AI
“The fluorine atom, in particular, often enhances the metabolic stability and lipophilicity of resulting molecules, making it highly sought after in drug discovery.”
Agile Vision 2025
“The ester group can undergo hydrolysis, reduction, or transesterification, while the aromatic ring can participate in electrophilic aromatic substitution reactions, albeit influenced by the existing substituents.”