For chemists and materials scientists, a deep understanding of a compound's chemical properties is the foundation for its effective utilization. (R)-2-(2-Chlorophenyl)-2-hydroxyacetic acid, with CAS number 52950-18-2, is a compound whose structural features dictate its reactivity and applications, particularly in chiral synthesis.

At its core, (R)-2-(2-Chlorophenyl)-2-hydroxyacetic acid is a derivative of mandelic acid, featuring a phenyl ring substituted with a chlorine atom at the ortho (2-) position. The presence of the hydroxyl group attached to the chiral carbon atom (designated as 'R' in this specific isomer) and the carboxylic acid group are key to its chemical behavior. Its molecular formula, C8H7ClO3, and a molecular weight of approximately 186.59 g/mol, provide basic physical characteristics. Typically appearing as a white powder, its melting point range of 119-121°C offers a preliminary indicator of its purity.

The reactivity of (R)-2-(2-Chlorophenyl)-2-hydroxyacetic acid stems from its functional groups. The carboxylic acid moiety readily undergoes esterification and amidation reactions, forming new covalent bonds crucial for building larger molecules. The secondary alcohol can be oxidized to a ketone or participate in ether formation. The chlorinated aromatic ring is susceptible to nucleophilic aromatic substitution under certain conditions or can be a target for palladium-catalyzed cross-coupling reactions, allowing for the introduction of diverse organic fragments.

This versatility makes it a sought-after intermediate when precise molecular design is required. When considering procurement, buyers often look for specific purity levels, often above 97%, and confirmation of the 'R' enantiomeric configuration. Companies that buy this intermediate from manufacturers in China can leverage the competitive prices and large-scale production capabilities offered. A reliable supplier will provide comprehensive technical data, including spectral analyses, to confirm the compound's identity and purity.

In summary, the chemical properties of (R)-2-(2-Chlorophenyl)-2-hydroxyacetic acid, characterized by its chiral center, reactive functional groups, and substituted aromatic ring, position it as a valuable component in advanced organic synthesis. Understanding these properties is the first step for any chemist or procurement specialist looking to effectively source and utilize this important intermediate.