In the competitive landscape of pharmaceutical development, having access to high-quality, versatile chemical intermediates is paramount. 3-Bromo-4-chloropyridine (CAS: 36953-42-1) stands out as a critically important building block for synthesis professionals. Its unique structural features, including two different halogen atoms on a pyridine ring, offer distinct advantages for complex organic synthesis. If you are a procurement manager or R&D scientist looking for this compound, understanding its applications and where to find a reliable manufacturer is key.

The Chemical Profile of 3-Bromo-4-chloropyridine

This compound is characterized by its molecular formula C5H3BrClN and a molecular weight of 192.44 g/mol. It typically appears as a light yellow to brown liquid. The presence of both bromine at the 3-position and chlorine at the 4-position on the pyridine ring is what makes it so synthetically valuable. This specific arrangement allows for regioselective reactions, meaning chemists can target one halogen over the other under carefully controlled conditions. This selectivity is a major advantage when constructing complex molecules where precise functionalization is required.

Synthetic Versatility: A Boon for R&D

The real power of 3-Bromo-4-chloropyridine lies in its reactivity. It readily participates in a variety of important chemical transformations:

  • Nucleophilic Aromatic Substitution (SNAr): The chlorine atom at the 4-position is activated by the ring nitrogen, making it susceptible to displacement by various nucleophiles like amines, alkoxides, and thiols. This allows for the introduction of diverse functional groups crucial for drug design.
  • Metal-Catalyzed Cross-Coupling Reactions: This is where 3-Bromo-4-chloropyridine truly shines. The C-Br bond at the 3-position is generally more reactive than the C-Cl bond in palladium-catalyzed reactions such as Suzuki-Miyaura, Negishi, and Sonogashira couplings. This differential reactivity enables chemists to selectively couple aryl or alkyl groups at the 3-position, while leaving the chlorine atom available for further functionalization or as a required moiety in the final product. This makes it an indispensable intermediate for pharmaceutical manufacturers looking to buy custom synthesis precursors.

Applications in Pharmaceutical Manufacturing

The primary application for 3-Bromo-4-chloropyridine is as an intermediate in the synthesis of Active Pharmaceutical Ingredients (APIs). Its structure is found embedded in or used to construct molecules targeting a range of therapeutic areas, including oncology, neurology, and inflammatory diseases. For instance, it has been instrumental in the synthesis of novel inhibitors for enzymes like Cholesterol 24-hydroxylase (CH24H), which is implicated in neurological disorders. Researchers utilize this compound to build complex molecular scaffolds that are then refined to achieve high potency and selectivity.

Beyond drug discovery, it also finds use in the development of agrochemicals, contributing to the creation of more effective pesticides and herbicides. This broad applicability underscores its importance across multiple sectors of the chemical industry.

Sourcing High-Quality 3-Bromo-4-chloropyridine

For any pharmaceutical or chemical company, securing a reliable supply of high-purity intermediates is critical. When looking to buy 3-Bromo-4-chloropyridine, it is essential to partner with reputable manufacturers. As a leading supplier based in China, we understand the importance of consistent quality, competitive pricing, and timely delivery. Our commitment to stringent quality control ensures that each batch meets the highest standards, providing you with the confidence to proceed with your critical synthesis projects. We offer this vital compound at competitive prices, making it an accessible and cost-effective choice for your procurement needs.

In conclusion, 3-Bromo-4-chloropyridine is far more than just a chemical compound; it is a gateway to innovation in pharmaceutical and chemical manufacturing. By understanding its properties and applications, and by choosing a trusted manufacturer, you can significantly advance your research and production goals.