In the intricate world of pharmaceutical research and development, the availability of high-quality, specialized chemical intermediates is paramount. One such crucial compound is 4-(Trifluoromethyl)pyridin-3-ol, identified by the CAS number 936841-71-3. This article delves into why this particular molecule is gaining traction among R&D scientists and procurement managers, and what makes sourcing it from reputable manufacturers in China a strategic advantage.

Understanding 4-(Trifluoromethyl)pyridin-3-ol: Properties and Significance

4-(Trifluoromethyl)pyridin-3-ol is a pyridine derivative that features a trifluoromethyl group (-CF3) and a hydroxyl group (-OH) attached to the pyridine ring. Its molecular formula is C6H4F3NO, with a molecular weight of 163.1 g/mol. Typically supplied as a white to yellow solid with a purity of 99% or higher, it is stable under recommended storage conditions (inert atmosphere, 2-8°C). The presence of the trifluoromethyl group is particularly noteworthy. This electron-withdrawing group often imparts unique physicochemical and pharmacokinetic properties to drug candidates, such as increased metabolic stability, enhanced lipophilicity, and improved binding affinity to target proteins. This makes compounds incorporating this moiety highly desirable in medicinal chemistry.

The Role in Pharmaceutical Synthesis

The primary application of 4-(Trifluoromethyl)pyridin-3-ol lies in its use as a versatile building block or intermediate in the synthesis of Active Pharmaceutical Ingredients (APIs). It serves as a scaffold for constructing more complex molecular structures that form the basis of new drugs. Its reactivity and the specific electronic and steric properties conferred by its functional groups allow chemists to introduce it into various synthetic pathways, leading to compounds with potential therapeutic activity across a range of disease areas.

For researchers looking to buy 4-(trifluoromethyl)pyridin-3-ol, the key is to ensure consistent quality and a reliable supply. The high purity of the intermediate is critical; impurities can lead to unwanted side reactions, reduced yields, and potentially compromise the safety and efficacy of the final drug product. This is where partnering with an experienced manufacturer becomes indispensable.

Sourcing from China: A Strategic Advantage

China has emerged as a global hub for chemical manufacturing, offering a wide array of intermediates with competitive pricing and often high quality. For a specialized compound like 4-(Trifluoromethyl)pyridin-3-ol, choosing a Chinese supplier can offer significant benefits. Leading Chinese chemical companies specialize in the production of these complex molecules, leveraging advanced synthesis techniques and stringent quality control measures. When you seek to purchase 4-(trifluoromethyl)pyridin-3-ol, looking for a reputable Chinese manufacturer can provide access to better price points and larger quantities, crucial for both R&D phases and eventual scale-up.

When engaging with a Chinese manufacturer for cas 936841-71-3, it is advisable to inquire about their production capacity, quality certifications, and sample availability. Many suppliers offer free samples, allowing researchers to test the material's suitability for their specific applications before committing to a large buy. Understanding their capabilities for custom synthesis can also be beneficial if minor modifications or specific grades are required for your project.

Conclusion

4-(Trifluoromethyl)pyridin-3-ol is more than just a chemical compound; it's an enabler of pharmaceutical innovation. Its unique structural features make it a valuable asset in the drug discovery pipeline. For R&D scientists and procurement professionals, understanding its importance and knowing where to source it reliably is key to efficient and successful drug development. By partnering with trusted manufacturers and suppliers of this critical intermediate, you can accelerate your research and bring new therapies to market faster.