In the intricate field of peptide synthesis, selecting the right amino acid derivatives can significantly impact the success and efficiency of your research or manufacturing processes. Fmoc-D-cyclopentylglycine, bearing the CAS number 136555-16-3, is a specialized building block that offers distinct advantages for creating peptides with tailored properties. This article explores why this particular amino acid derivative is valuable and guides procurement professionals and research scientists on its acquisition.

Fmoc-D-cyclopentylglycine is an unnatural amino acid derivative that combines the benefits of the Fmoc (9-fluorenylmethoxycarbonyl) protecting group with a D-stereospecific cyclopentyl side chain. The Fmoc group is a standard in solid-phase peptide synthesis (SPPS), allowing for controlled and efficient peptide chain elongation under basic conditions. The D-configuration and the cyclopentyl ring on the alpha-carbon are key to its unique utility. The D-amino acid component can introduce resistance to enzymatic degradation, which is often a limitation for naturally occurring L-amino acid peptides. The cyclopentyl ring itself adds hydrophobicity and can influence the peptide's conformational structure, potentially leading to enhanced receptor binding or improved pharmacokinetic properties.

For research and development applications, especially in the pharmaceutical industry, these properties are highly desirable. They can be leveraged to design peptide therapeutics with extended half-lives, improved cellular uptake, or greater stability in biological systems. Peptide scientists often incorporate Fmoc-D-cyclopentylglycine to explore structure-activity relationships (SAR) or to develop peptide analogs with superior efficacy or reduced side effects. Its role as a specialty intermediate makes it a vital component for cutting-edge peptide design.

When it comes to purchasing Fmoc-D-cyclopentylglycine, it is critical to partner with reliable manufacturers and suppliers. Quality and consistency are paramount. Look for suppliers who can provide high-purity material, typically exceeding 97% by HPLC, along with comprehensive documentation such as Certificates of Analysis (COA). Manufacturers based in China are often a strong choice for procurement professionals looking for cost-effective sourcing without compromising on quality. Ensuring a stable supply chain is also important for ongoing research projects or larger-scale production.

In summary, Fmoc-D-cyclopentylglycine is more than just another amino acid derivative; it's a tool that empowers researchers to push the boundaries of peptide science. Whether you are synthesizing peptides for drug discovery, diagnostics, or novel materials, understanding the benefits of this compound and sourcing it from a trusted manufacturer will be instrumental to your success. Consider us your reliable partner for this essential peptide synthesis building block.