For organic chemists and researchers in the fine chemical sector, identifying versatile building blocks is key to unlocking new synthetic pathways and developing novel compounds. 2-[[(2,4-Difluorophenyl)-2-oxiranyl]methyl]-1H-1,2,4-triazole Methanesulfonate, identified by its CAS number 86386-77-8, is one such compound that offers significant potential due to its unique chemical architecture. This article explores the chemistry of this intermediate, its role in organic synthesis, and how to approach its purchase from reliable manufacturers and suppliers.

Deconstructing the Molecule: Structure and Reactivity

The chemical structure of 86386-77-8 (Molecular Formula: C11H9F2N3O.CH4O3S; Molecular Weight: 333.31) is rich in functional groups that dictate its reactivity and utility. Key features include:

  • Difluorophenyl Ring: The presence of two fluorine atoms on the phenyl ring can influence electron density, lipophilicity, and metabolic stability in derived compounds.
  • Epoxide Ring: The oxirane (epoxide) group is highly reactive and susceptible to nucleophilic attack, making it an excellent handle for introducing new substituents or forming cyclic structures.
  • 1,2,4-Triazole Ring: This nitrogen-rich heterocycle is known for its aromatic stability and its ability to participate in coordination chemistry, hydrogen bonding, and as a pharmacophore in drug design.
  • Methanesulfonate Salt: The presence of the methanesulfonate counterion generally enhances solubility and stability compared to the free base, making it easier to handle and formulate.

These combined features make 2-[[(2,4-Difluorophenyl)-2-oxiranyl]methyl]-1H-1,2,4-triazole Methanesulfonate an attractive starting material for a wide range of synthetic transformations.

Applications in Organic Synthesis

As a versatile building block, CAS 86386-77-8 finds applications in:

  • Synthesis of Heterocyclic Compounds: The epoxide can react with various nucleophiles (amines, alcohols, thiols) to form new carbon-heteroatom bonds, leading to more complex heterocyclic systems.
  • Formation of Functionalized Intermediates: It can be used to introduce the difluorophenyl-triazole moiety into larger molecular frameworks, which is particularly relevant for the development of pharmaceutical intermediates and advanced materials in electronic chemicals.
  • Chiral Synthesis: If the epoxide is enantiomerically pure, it can be a precursor for chiral molecules, which are crucial in the pharmaceutical industry.

Procurement and Supply from Manufacturers

For researchers and industrial chemists looking to buy 86386-77-8, securing a reliable supply is essential. Companies interested in this compound should look to experienced chemical manufacturers and suppliers, particularly those based in regions with strong chemical production infrastructure like China. When evaluating potential sources, consider the following:

  • Product Purity and CoA: Always request a Certificate of Analysis to confirm purity levels and identify any impurities.
  • Bulk Purchase Options: If scaling up research or entering production, inquire about bulk quantities and their associated price advantages.
  • Technical Data Sheets: Access to detailed technical information about handling, storage, and reactivity is invaluable.

Conclusion: A Key Component for Chemical Innovation

The intricate structure and inherent reactivity of 2-[[(2,4-Difluorophenyl)-2-oxiranyl]methyl]-1H-1,2,4-triazole Methanesulfonate (CAS 86386-77-8) position it as a valuable asset in the toolkit of synthetic organic chemists. Whether for developing new pharmaceuticals, advanced electronic materials, or other fine chemicals, this intermediate offers a potent starting point. When planning to purchase this compound, partnering with reputable manufacturers and suppliers who can offer it at a competitive price with assured quality is a critical step towards successful research and development outcomes.