In the dynamic field of chemical manufacturing, understanding the properties and applications of key chemical intermediates is crucial for innovation and efficient production. Chlorodi(p-tolyl)phosphine, bearing the CAS number 1019-71-2, is a significant organophosphorus compound that serves multiple critical roles, particularly in catalysis and the synthesis of advanced materials. As a leading manufacturer and supplier of fine chemicals, we provide detailed insights into this versatile compound, helping professionals make informed decisions when they need to buy Chlorodi(p-tolyl)phosphine.

The chemical structure of Chlorodi(p-tolyl)phosphine (C14H14ClP) features a phosphorus atom bonded to a chlorine atom and two p-tolyl groups. This arrangement gives it specific reactivity and coordination properties that are highly valued in synthetic organic chemistry. Its molecular weight is approximately 248.69 g/mol. Importantly, it is sensitive to air and moisture, and it reacts with water, necessitating careful handling and storage. Its classification as a corrosive substance also dictates specific safety protocols.

Key Chemical Properties and Handling

Understanding the physicochemical properties of Chlorodi(p-tolyl)phosphine is essential for its effective use and safe handling:

  • Appearance and Form: Typically, it presents as a colorless to light yellow viscous liquid.
  • Reactivity: It is sensitive to air and moisture, readily reacting with water. This sensitivity means it should be stored under an inert atmosphere (like nitrogen or argon) to maintain its integrity and reactivity.
  • Boiling Point: It has a boiling point of approximately 180-184°C at 10 mmHg, indicating its stability under moderate thermal conditions.
  • Density: Its density is around 1.1 g/mL at 25°C.
  • Safety Profile: It is classified as corrosive and requires appropriate personal protective equipment (PPE) such as gloves, safety goggles, and lab coats when handled. Always consult the Material Safety Data Sheet (MSDS) for comprehensive safety guidelines.

Diverse Applications in Chemical Synthesis

The utility of Chlorodi(p-tolyl)phosphine spans several critical areas within the chemical industry:

  • Palladium-Catalyzed Cross-Coupling Reactions: It is a vital precursor for synthesizing palladium catalysts that are fundamental for forming carbon-carbon bonds. Reactions like Suzuki-Miyaura, Heck, and Sonogashira couplings, widely used in pharmaceutical and agrochemical synthesis, rely on such advanced catalytic systems.
  • Nickel Catalysis: Chlorodi(p-tolyl)phosphine acts as an important ligand in nickel-catalyzed reactions, including isomerization and oligomerization processes, contributing to the development of new catalytic methodologies.
  • Phosphinylation Reagent: It serves as a direct reagent for introducing the di(p-tolyl)phosphino group into molecules, which is a key step in creating specialized organophosphorus compounds for various applications, including electronic materials.

Sourcing High-Quality Chlorodi(p-tolyl)phosphine

As a prominent chemical supplier based in China, we are dedicated to providing high-purity Chlorodi(p-tolyl)phosphine. We understand the rigorous demands of the chemical synthesis sector and strive to offer reliable sourcing solutions. When you choose to buy from us, you are assured of consistent quality, competitive pricing, and thorough technical support, making us your trusted partner for essential chemical intermediates.