For B2B procurement managers, R&D scientists, and formulation chemists, understanding the intrinsic properties and synthesis of key chemical intermediates is paramount. This article provides an in-depth look at 4-Amino-2-Chloropyridine (CAS 14432-12-3), a compound vital to various industries, from agrochemicals to pharmaceuticals. As a prominent manufacturer and supplier in China, NINGBO INNO PHARMCHEM CO.,LTD. is dedicated to providing clear, technical insights into the materials we supply.

Chemical Profile and Properties:
4-Amino-2-Chloropyridine (CAS 14432-12-3) typically presents as a white crystalline powder. Its key physical properties include a melting point around 89-94°C and a molecular formula of C5H5ClN2, with a molecular weight of 128.56. While slightly soluble in water, it exhibits good solubility in common organic solvents like methanol, ethanol, and DMSO. Its stability under normal temperature and pressure makes it a practical intermediate for various chemical processes. The compound's chemical reactivity is characteristic of its functional groups – an amine and a chlorinated pyridine ring – enabling it to participate in a range of synthetic transformations.

Synthesis Routes:
The preparation of 4-Amino-2-Chloropyridine often involves multi-step synthesis pathways. One common method starts with isonicotinic acid, which is chlorinated using phosphorus oxychloride to yield 2-chloropyridine-4-carboxylic acid. This intermediate then reacts with ammonia gas to form the corresponding amide, followed by a Hofmann degradation reaction to produce the final product. Alternative routes may utilize 2-chloropyridine-N-oxide as a starting material, involving nitration and subsequent reduction steps. Understanding these synthesis methods is crucial for appreciating the quality and potential impurities that might be present, underscoring the importance of sourcing from a reputable manufacturer.

Applications and Significance:
As previously discussed, 4-Amino-2-Chloropyridine is highly valued for its role in agrochemicals, particularly as a plant growth regulator due to its superior cytokinin-like activity. It is also a crucial intermediate in the synthesis of various pesticides. Furthermore, its utility extends to the pharmaceutical industry as a building block for APIs and to the pigment industry for creating specialized colorants. The consistent demand across these sectors highlights its importance as a versatile chemical intermediate. For procurement managers seeking to buy this compound, securing a supply from a reliable supplier in China with a proven track record in quality control and production capacity is essential. We ensure adherence to strict specifications, offering competitive prices and a stable supply chain to support your manufacturing needs.