2-Thiophenethiol, a compound identified by CAS number 7774-74-5, is a heterocyclic organosulfur compound that holds significant importance across various industries, from flavors and fragrances to pharmaceuticals and materials science. A thorough understanding of its properties, synthesis, and safety protocols is crucial for its effective and responsible utilization.

Physically, 2-thiophenethiol is typically described as a light yellow to orange liquid. Its characteristic odor is often noted as unpleasant, with descriptors including burnt caramel, coffee-like, and sulfurous. This potent aroma is precisely what makes it valuable as a flavor and fragrance intermediate. Key physical properties include a density of around 1.25 g/mL at 25°C and a boiling point of approximately 166-171°C at atmospheric pressure. Its refractive index is generally around 1.62. The compound is soluble in organic solvents like chloroform and DMSO, but only slightly soluble in water.

The synthesis of 2-thiophenethiol can be achieved through several methods. A common laboratory preparation involves the reaction of thiophene with a strong base like n-butyllithium, followed by reaction with sulfur. Industrial synthesis routes may vary but often leverage reactions involving thiophene derivatives and sulfur sources. The purity of the synthesized product is critical, with assays typically requiring ≥98.0% for most applications.

When it comes to safety considerations, 2-thiophenethiol warrants careful handling. It is classified as an irritant, with hazard statements indicating potential irritation to the skin, eyes, and respiratory system (H315, H319, H335). Appropriate personal protective equipment (PPE) is essential, including gloves, eye protection, and respiratory protection in well-ventilated areas. Storage recommendations often include keeping it in a cool, dark place under an inert atmosphere to prevent oxidation and degradation. MSDS (Material Safety Data Sheet) information should always be consulted prior to handling or use.

As a versatile chemical intermediate, reliable sourcing is key. Companies like NINGBO INNO PHARMCHEM CO.,LTD. provide high-purity 2-thiophenethiol, catering to the demanding requirements of various industries. Understanding these fundamental aspects ensures that chemists and formulators can effectively and safely integrate this valuable compound into their processes and products.