NINGBO INNO PHARMCHEM CO.,LTD. is dedicated to exploring the therapeutic potential of natural compounds, and Dihydromyricetin (DHM), also known as Ampelopsin, is a focal point for research into liver health, particularly concerning liver fibrosis.

Liver fibrosis is a serious condition where scar tissue builds up in the liver, often as a consequence of chronic inflammation or injury. This scarring can impair liver function and potentially lead to more severe conditions like cirrhosis. Traditional approaches to managing liver fibrosis are often limited, driving interest in natural interventions. Scientific studies have begun to elucidate the mechanisms by which DHM might offer protective effects against liver fibrosis.

One of the key areas of research focuses on DHM's interaction with hepatic stellate cells (HSCs). These are the primary cells responsible for producing the extracellular matrix that forms scar tissue in the liver. Emerging evidence suggests that DHM can inhibit the activation of HSCs. A significant proposed mechanism for this inhibition is DHM's ability to induce autophagy within these cells. Autophagy is a cellular process that removes damaged components, and its induction by DHM is believed to help in the inactivation of activated HSCs, thereby reducing the progression of fibrosis.

In addition to its direct cellular effects, DHM also influences the liver's immune microenvironment. Research indicates that DHM can enhance the activity of natural killer (NK) cells in the liver. Activated NK cells can secrete interferon-gamma (IFN-γ), a cytokine known to have anti-fibrotic properties by promoting the clearance of activated HSCs. By boosting NK cell function and IFN-γ production, DHM appears to provide an indirect yet powerful mechanism for combating liver fibrosis. The complex signaling pathways involving aryl hydrocarbon receptor (AhR), NF-κB, and STAT3 are being investigated as the underlying basis for DHM-induced NK cell activation and subsequent IFN-γ release.

The multifaceted action of dihydromyricetin—combining direct cellular modulation via autophagy with immune system enhancement—makes it a promising candidate for natural liver support. As research continues to uncover the depth of its benefits, DHM offers a ray of hope for individuals seeking natural ways to protect their liver health and manage conditions like liver fibrosis. Its potential roles in promoting autophagy and activating natural killer cells highlight its significant therapeutic promise.