Polyhexamethylene Biguanide Hydrochloride (PHMB), identified by CAS number 32289-58-0, is a remarkable polymer known for its potent antimicrobial properties. Understanding its chemical structure and the mechanism by which it exerts its biocidal action is key to appreciating its effectiveness and widespread use in industries ranging from cosmetics to water treatment. As a leading manufacturer and supplier of PHMB in China, we are pleased to share insights into this versatile chemical compound.

At its core, PHMB is a polymeric biguanide. Its chemical structure features repeating units of hexamethylene diamine linked by biguanide groups, with hydrochloride salts ensuring water solubility and stability. The positively charged biguanide groups are the key to its antimicrobial activity. In aqueous environments, PHMB dissociates, presenting a highly positively charged polymer chain.

The primary antimicrobial mechanism of PHMB involves electrostatic interaction with the negatively charged components of microbial cell membranes, such as phospholipids and lipopolysaccharides. This initial attraction leads to a disruption of the cell membrane's integrity. PHMB molecules are believed to insert themselves into the lipid bilayer, causing leakage of vital intracellular components like ions and nucleotides, and ultimately leading to cell death. This non-specific membrane-damaging action means that microbes have a significantly reduced ability to develop resistance compared to agents that target specific intracellular processes.

This robust mechanism makes PHMB effective against a broad spectrum of microorganisms, including bacteria (Gram-positive and Gram-negative), fungi, and yeast. When formulators decide to buy PHMB, they are choosing an ingredient with a well-understood and highly effective mode of action. As a reliable PHMB manufacturer and supplier, we offer PHMB in high-purity forms (20% liquid and 98% powder) to ensure optimal performance in your applications. Whether you are developing disinfectants, preservatives, or water treatment solutions, our PHMB provides a potent and adaptable antimicrobial foundation. We encourage you to inquire about our PHMB price and discover the advantages of this advanced chemical.