Fmoc-D-Thz-OH Bulk Price Global Manufacturer 2026
- Technical Grade: Delivers >98.5% purity via HPLC for rigorous peptide synthesis applications.
- Commercial Scale: Optimized manufacturing process ensures stable bulk price and supply continuity into 2026.
- Quality Compliance: Full documentation including COA, SDS, and manufacturing process validation provided.
In the landscape of modern pharmaceutical development, the demand for high-fidelity chiral building blocks is paramount. Fmoc-D-Thz-OH represents a critical protected amino acid utilized extensively in the construction of complex peptide therapeutics. As we approach 2026, procurement strategies must shift from small-scale laboratory sourcing to robust industrial partnerships. This analysis details the technical specifications, synthesis routes, and commercial frameworks required for securing this essential peptide building block at a competitive bulk price.
Technical Specifications and Physical Properties
Understanding the physicochemical profile of the material is the first step in vendor qualification. The D-isomer of thiazolidine-4-carboxylic acid protected with the 9-fluorenylmethyloxycarbonyl group possesses specific stereochemical properties that distinguish it from its L-enantiomer. Precision in optical rotation and purity is non-negotiable for downstream reaction yields.
| Property | Specification |
|---|---|
| Chemical Name | (R)-3-(((9H-Fluoren-9-yl)Methoxy)carbonyl)thiazolidine-4-carboxylic acid |
| CAS Number | 198545-89-0 |
| Molecular Formula | C19H17NO4S |
| Molecular Weight | 355.41 g/mol |
| Purity (HPLC) | >98.5% |
| Appearance | White to Off-White Solid |
| Storage Conditions | Sealed in dry environment, 2-8°C |
Maintaining industrial purity levels above 98.5% minimizes the formation of diastereomeric impurities during solid-phase peptide synthesis (SPPS). Impurities at the building block stage can propagate through the synthesis chain, drastically reducing final API yield and complicating purification protocols.
Synthesis Route and Manufacturing Process
The production of this Thz-OH derivative requires stringent control over stereochemistry. The standard synthesis route involves the condensation of D-thioproline with Fmoc-OSu or Fmoc-Cl under controlled pH conditions to prevent racemization. At NINGBO INNO PHARMCHEM CO.,LTD., the manufacturing process is optimized to maximize reaction yields while ensuring the optical integrity of the D-configuration.
Key process control points include:
- Raw Material Verification: Incoming D-thiaproline is assayed for enantiomeric excess prior to reaction.
- Reaction Monitoring: In-process controls utilize HPLC to monitor the completion of Fmoc protection.
- Crystallization: Purification is achieved through controlled crystallization to remove unreacted starting materials and side products.
This rigorous approach ensures that every batch meets the stringent requirements of GMP-aligned peptide synthesis. When sourcing high-purity Fmoc-D-Thiazolidine-4-Carboxylic Acid, buyers should verify that the supplier employs chiral chromatography methods to confirm stereochemical purity.
Volume-Based Pricing Structures for Bulk Orders
Market intelligence for 2026 indicates a stabilization in raw material costs, allowing for more predictable budgeting for large-scale projects. While laboratory-grade packages (1g to 5g) command a premium due to packaging and handling overheads, kilogram-scale procurement offers significant cost efficiencies. The bulk price is heavily influenced by order volume and contract duration.
| Order Volume | Packaging | Estimated Lead Time |
|---|---|---|
| 10g - 100g | Double LDPE bag inside aluminum foil bag | 3-5 Days |
| 100g - 1kg | Double LDPE bag inside aluminum foil bag | 5-7 Days |
| 1kg - 25kg | Carton or Drum with desiccant | 7-14 Days |
| 25kg+ | Customized Industrial Drum | 14-21 Days |
As a global manufacturer, we recognize that supply chain reliability is as critical as cost. Long-term supply agreements can lock in pricing, protecting projects from market volatility. Clients are encouraged to request custom synthesis quotes for non-standard packaging or specific purity upgrades beyond the standard 98.5% threshold.
Quality Assurance and Documentation
Regulatory compliance requires comprehensive documentation. Every shipment of Fmoc-D-Thiazolidine must be accompanied by a valid Certificate of Analysis (COA). This document verifies the identity, purity, and physical properties of the batch against established specifications.
Essential documentation includes:
- Certificate of Analysis (COA): Details HPLC purity, optical rotation, and loss on drying.
- Safety Data Sheet (SDS): Provides handling, storage, and disposal safety information.
- Certificate of Origin (COO): Confirms manufacturing origin for customs and trade compliance.
Quality assurance protocols extend beyond the final product. Raw material sourcing, equipment calibration, and personnel training are all audited to ensure consistency. For pharmaceutical clients, additional support such as DMF filing assistance or specific impurity profiling can be arranged through custom synthesis channels.
Global Shipping and Logistics Cost Analysis
Efficient logistics are vital for maintaining the integrity of temperature-sensitive materials. While this compound is stable under recommended conditions, exposure to moisture or excessive heat can degrade the Fmoc group. Shipping protocols involve vacuum-sealed packaging with desiccants to ensure stability during transit.
Logistics costs are calculated based on weight, volume, and destination. Air freight is recommended for urgent small-scale requirements, while sea freight offers cost savings for bulk industrial orders. Proper classification under HS Code 29225090 ensures smooth customs clearance. Partnering with a dedicated manufacturer like NINGBO INNO PHARMCHEM CO.,LTD. streamlines this process, as export documentation is prepared in-house to minimize delays.
Conclusion
Securing a reliable supply of Fmoc-D-Thz-OH is a strategic decision for any peptide synthesis operation. The focus must remain on technical capability, purity assurance, and scalable production capacity. By prioritizing manufacturers who offer transparent quality assurance and competitive bulk price structures, organizations can mitigate risk and ensure project continuity through 2026 and beyond.
For technical inquiries or to request a sample for qualification, contact our sales team to discuss your specific requirements for this critical protected amino acid.