Prezatide Copper Acetate COA and Technical Specifications: Ensuring Quality for Advanced Cosmetic Formulations
- Prezatide copper acetate must meet strict COA criteria including ≥95% assay purity, correct molecular weight (862.4 g/mol), and verified identity via IUPAC name and CAS number.
- As a copper tripeptide-1 analog with the chemical structure (2S)-6-amino-2-[[(2S)-2-[(2-aminoacetyl)amino]-3-(1H-imidazol-5-yl)propanoyl]amino]hexanoic acid, it functions as a potent skin-conditioning agent that stimulates collagen synthesis and angiogenesis.
- When sourcing high-purity drop-in replacement materials, buyers should prioritize suppliers offering full traceability, batch-specific COAs, and formulation compatibility data.
In the competitive landscape of bioactive cosmetic ingredients, Prezatide copper acetate (CAS: 130120-57-9) stands out as a scientifically validated copper peptide complex renowned for its role in skin repair, anti-aging, and wound healing. As demand grows for transparent quality assurance, understanding its Certificate of Analysis (COA) parameters and technical specifications is essential for formulators, procurement specialists, and R&D teams seeking reliable, high-performance raw materials.
Decoding the Certificate of Analysis (COA) for Prezatide Copper Acetate
A robust COA is the cornerstone of quality validation for any active pharmaceutical or cosmetic ingredient. For Prezatide copper acetate, key COA parameters include:
- Assay Purity: Reputable manufacturers consistently deliver ≥95% assay by HPLC, with premium batches reaching 98–99.9%. This ensures maximum biological efficacy and minimal impurities that could compromise formulation stability.
- Appearance: Typically a blue to bluish-violet lyophilized powder—any deviation may indicate degradation or incorrect stoichiometry.
- Molecular Formula & Weight: Confirmed as C32H54CuN12O12 (MW: 862.4 g/mol), aligning with the IUPAC designation: copper; acetic acid; bis((2S)-6-amino-2-[[(2S)-2-[(2-aminoacetyl)amino]-3-(1H-imidazol-5-yl)propanoyl]amino]hexanoate).
- Identity Verification: Validated through NMR, MS, and FTIR against reference standards.
- Heavy Metals & Residual Solvents: Must comply with ICH Q3 guidelines—especially critical given the copper content.
Technical Profile: From GHK-Cu Derivative to Functional Active
Prezatide copper acetate is a stabilized analog of the naturally occurring copper tripeptide-1, often referred to in literature as a GHK-Cu derivative. Its core structure—(2S)-6-amino-2-[[(2S)-2-[(2-aminoacetyl)amino]-3-(1H-imidazol-5-yl)propanoyl]amino]hexanoic acid—chelates copper(II) ions in a 2:1 peptide-to-metal ratio, forming the dominant bis-complex at physiological pH.
This configuration enables multifunctional activity:
- Collagen & Elastin Synthesis: Upregulates Type I and III collagen via TGF-β pathways and enhances lysyl oxidase activity—a copper-dependent enzyme critical for collagen cross-linking.
- Angiogenesis: Activates VEGF and promotes capillary endothelial cell migration, accelerating tissue regeneration.
- Anti-Inflammatory Action: Suppresses pro-inflammatory cytokines (e.g., IL-6, TNF-α) while recruiting macrophages and fibroblasts to injury sites.
- Oxidative Stress Mitigation: Enhances mitochondrial function through SIRT1/Nrf2/PGC-1α signaling, reducing ROS damage in aging skin.
Formulation Considerations and Performance Benchmarking
Despite its efficacy, Prezatide copper acetate presents formulation challenges due to potential instability in aqueous systems and sensitivity to pH extremes. Successful integration requires:
- pH optimization (typically 5.5–6.5)
- Chelating agents to prevent metal displacement
- Encapsulation or hydrogel delivery systems to enhance shelf life
For brands seeking a reliable equivalent or performance benchmark against legacy copper peptides, Prezatide offers superior batch-to-batch consistency and enhanced solubility profiles when sourced from qualified manufacturers.
Global Supply and Commercial Viability
As a global manufacturer with GMP-compliant facilities, NINGBO INNO PHARMCHEM CO.,LTD. provides bulk quantities of Prezatide copper acetate with full documentation, including batch-specific COAs, safety data sheets (SDS), and regulatory support for global markets. The company’s technical team also offers a detailed formulation guide to assist clients in optimizing stability and bioavailability in serums, creams, and medical-grade gels.
With scalable production capacity and rigorous QC protocols, NINGBO INNO PHARMCHEM CO.,LTD. ensures that every kilogram meets the highest standards for purity, identity, and functional performance—making it a trusted partner for cosmetic and dermatological innovators worldwide.
Technical Specifications Summary Table
| Parameter | Specification |
|---|---|
| CAS Number | 130120-57-9 |
| IUPAC Name | copper; acetic acid; bis((2S)-6-amino-2-[[(2S)-2-[(2-aminoacetyl)amino]-3-(1H-imidazol-5-yl)propanoyl]amino]hexanoate) |
| Molecular Formula | C32H54CuN12O12 |
| Molecular Weight | 862.4 g/mol |
| Assay (HPLC) | ≥95% (typically 98–99.9%) |
| Appearance | Blue to bluish-violet lyophilized powder |
| Solubility | Soluble in water and dilute acetic acid |
| Primary Function | Skin conditioning, collagen synthesis, anti-inflammatory, wound healing |
| Recommended Use Level | 0.01% – 0.1% in final formulations |
For R&D teams evaluating next-generation copper peptides, Prezatide copper acetate represents a scientifically grounded, commercially viable option. By partnering with a premier supplier like NINGBO INNO PHARMCHEM CO.,LTD., formulators gain access not only to high-purity material but also to technical expertise that bridges laboratory innovation and market-ready product development.