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For chemists and researchers in the pharmaceutical and fine chemical industries, a thorough understanding of key intermediates is crucial for successful project outcomes. 1-(2,3-Dichlorophenyl)piperazine, identified by its CAS number 41202-77-1, is one such compound that warrants detailed examination due to its versatile chemical properties and significant role in organic synthesis.
Chemical Profile and Key Properties
1-(2,3-Dichlorophenyl)piperazine (DCPP) is an organic compound with the molecular formula C10H12Cl2N2 and a molecular weight of approximately 231.12 g/mol. It is characterized by the presence of a phenyl ring substituted with two chlorine atoms at the 2 and 3 positions, attached to a piperazine ring. This structural motif makes it a valuable synthon in medicinal chemistry and organic synthesis. Common physical properties reported for DCPP include a melting point typically in the range of 242-244°C (for the hydrochloride salt) and a density around 1.272 g/cm³. Its appearance is generally described as a white or off-white powder.
Applications in Organic Synthesis and Pharmaceuticals
The primary application of 1-(2,3-Dichlorophenyl)piperazine lies in its utility as a crucial intermediate in the synthesis of pharmaceuticals. Its most notable use is as a precursor in the manufacturing of Aripiprazole, an atypical antipsychotic. The specific arrangement of atoms in DCPP allows for precise chemical transformations necessary to build the complex structure of Aripiprazole, which acts on dopamine and serotonin receptors.
Beyond its role in Aripiprazole synthesis, DCPP also serves as a versatile building block in general organic synthesis. Researchers can utilize its reactive sites to introduce the dichlorophenylpiperazine moiety into various other molecular scaffolds, exploring new chemical entities for potential therapeutic applications or novel material properties. Its availability from reliable chemical suppliers ensures that R&D professionals can readily access this compound for their experiments.
Sourcing Considerations for DCPP
When sourcing 1-(2,3-Dichlorophenyl)piperazine for research or manufacturing, it is essential to partner with reputable suppliers who can guarantee product quality and consistency. Factors such as purity (often specified as ≥99.0% by HPLC), reliable lead times, and comprehensive technical documentation (including SDS and CoA) are critical. Manufacturers and suppliers in China offer competitive pricing and robust quality control, making them attractive partners for businesses worldwide looking to buy this essential chemical intermediate. We are dedicated to providing high-quality DCPP and welcome inquiries for quotes and samples to support your synthesis projects.
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