1,3,5-Tris(p-formylphenyl)benzene (TFPB): A Versatile Building Block for Advanced Materials

In the expansive realm of chemical synthesis, certain compounds stand out for their exceptional versatility and pivotal role in enabling groundbreaking innovations. Among these is 1,3,5-Tris(p-formylphenyl)benzene, identified by its CAS number 118688-53-2. This organic compound, characterized by the molecular formula C27H18O3 and a molecular weight of 390.43 g/mol, presents as an off-white solid or powder. With a melting point typically ranging from 248.0 to 252.0 degrees Celsius, TFPB is a highly pure material, often exceeding 98% purity, making it indispensable for a wide array of high-precision applications.

The unique chemical structure of 1,3,5-Tris(p-formylphenyl)benzene, featuring a central benzene ring adorned with three formylphenyl groups, bestows upon it exceptional reactivity and functionality. This makes it a crucial intermediate in numerous organic syntheses, serving as a fundamental building block in both laboratory research and large-scale industrial processes. Its aldehyde groups provide facile reaction pathways, particularly with amine derivatives, leading to the formation of imine linkages—a key characteristic exploited in the synthesis of cutting-edge materials.

One of the most significant applications of 1,3,5-Tris(p-formylphenyl)benzene lies in its role as a fundamental ligand for the construction of Covalent Organic Frameworks (COFs) and Metal-Organic Frameworks (MOFs). These porous crystalline materials are revolutionizing various fields due to their high surface areas, tunable pore sizes, and exceptional stability. For instance, TFPB is instrumental in creating COFs tailored for environmental applications, such as efficient carbon dioxide (CO2) adsorption. A notable example is a benzothiazole COF, synthesized using TFPB, which demonstrates a remarkable CO2 adsorption capacity of 7.8 wt% at 273 K/bar and exhibits thermal stability up to an impressive 450 °C under a nitrogen atmosphere. Furthermore, TFPB facilitates the synthesis of two-dimensional semiconducting COFs through Knoevenagel condensation, leading to materials capable of photocatalytic hydrogen evolution, with reported production rates of 2.9 μmol/h.

Beyond material science, 1,3,5-Tris(p-formylphenyl)benzene is recognized as a vital pharmaceutical intermediate. Its distinct configuration and properties render it an invaluable cornerstone in the biomedical sector, contributing to the advancement of groundbreaking pharmaceutical formulations. Research indicates its utility in the synthesis of compounds aimed at combating various ailments, including cancer and inflammation. Moreover, TFPB has shown promise in environmental remediation efforts, particularly in wastewater treatment, where it can be utilized to remove harmful contaminants such as fluoroquinolones and pesticides from plasma samples and industrial effluents. Its electron-deficient nature and ability to react effectively with imines further underscore its broad applicability in diverse chemical transformations.

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