1-(4-Aminophenyl)-5,6-dihydro-3-(4-morpholinyl)-2(1H)-pyridinone, identified by its CAS Registry Number 1267610-26-3, stands as a pivotal chemical compound in the pharmaceutical industry. This intermediate, often referred to by synonyms such as 1-(4-aminophenyl)-3-morpholino-5,6-dihydropyridin-2(1H)-one, is of paramount importance due to its indispensable role in the synthesis of Apixaban, a widely recognized anticoagulant medication. Its unique molecular structure, represented by the formula C15H19N3O2 and a molecular weight of 273.330, underpins its specific chemical reactivity and utility in complex organic syntheses. As a critical building block, its consistent quality and availability are essential for the efficient production of life-saving therapeutics.

The physical and chemical properties of 1-(4-aminophenyl)-5,6-dihydro-3-(4-morpholinyl)-2(1H)-pyridinone are well-characterized, ensuring its safe handling and effective application in various processes. It typically presents as an off-white to light beige powder, indicating its solid form at room temperature. Key specifications include an assay purity of greater than or equal to 98.0%, affirming its high quality for pharmaceutical use. Predicted properties include a density of approximately 1.277 g/cm3, a boiling point of around 491.5 °C at 760 mmHg, and a flash point of about 251.0 °C. Its melting point is reported to be above 246°C (with decomposition). For optimal preservation of its stability and chemical integrity, it is recommended to store this compound in a cool, ventilated place, preferably under an inert gas like nitrogen or argon, at temperatures between 2-8 °C. It exhibits slight solubility in common organic solvents such as chloroform and methanol.

The primary and most significant application of 1-(4-aminophenyl)-5,6-dihydro-3-(4-morpholinyl)-2(1H)-pyridinone lies in its function as a key intermediate for Apixaban (CAS: 503612-47-3). Apixaban is a highly effective, direct, selective, and orally active inhibitor of coagulation factor Xa. This makes it a crucial pharmaceutical agent used globally for the prevention of venous thromboembolism (VTE), particularly in patients undergoing total hip or knee replacement orthopedic surgery. Furthermore, it plays a vital role in preventing stroke in individuals with venous thromboembolic disorders or atrial fibrillation. The synthesis process of Apixaban critically relies on the purity and consistent quality of this intermediate, directly impacting the efficacy and safety of the final drug product.

Beyond its specific role in Apixaban synthesis, this compound serves more broadly as an invaluable organic synthesis intermediate and pharmaceutical intermediate. Its utility extends to various laboratory research and development processes, as well as large-scale chemical production. Research institutions and drug manufacturers depend on reliable sources for such specialized chemical building blocks to advance medical science and bring new treatments to market. The rigorous quality control measures applied during its production ensure that it meets the stringent requirements of the pharmaceutical industry, upholding both safety and performance standards.

For those looking to buy or purchase this essential Apixaban intermediate, NINGBO INNO PHARMCHEM CO.,LTD. stands as a trusted manufacturer and supplier. We are committed to providing high-quality 1-(4-aminophenyl)-5,6-dihydro-3-(4-morpholinyl)-2(1H)-pyridinone, packed typically in 25 kg drums, with options for customized packaging to meet specific customer requirements. Our dedication to quality assurance and efficient supply chain management ensures that clients receive products that adhere to the highest industry standards. For inquiries regarding price, availability, or to discuss specific bulk purchase needs, potential buyers are encouraged to reach out. Obtaining this critical intermediate from a reliable supplier like NINGBO INNO PHARMCHEM CO.,LTD. guarantees consistency and compliance, which are paramount for successful pharmaceutical development and manufacturing.