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1,4-Bis(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzene: A Key Pharma Intermediate

In the intricate landscape of pharmaceutical manufacturing, the role of high-quality intermediates cannot be overstated. Among these essential compounds, 1,4-Bis(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzene, identified by its CAS NO: 99770-93-1, stands out as a crucial building block. This compound, typically a white to pale yellow powder with a minimum purity of 98%, possesses precise molecular characteristics, including a molecular formula of C18H28B2O4 and a molecular weight of 330.034. Its well-defined boiling point (416.3±28.0 °C at 760 mmHg) and melting point (241-245ºC) underscore its chemical stability and suitability for rigorous synthetic processes.


Pharmaceutical intermediates are best understood as sophisticated chemical compounds or 'semi-finished products' that are indispensable at various stages of Active Pharmaceutical Ingredient (API) synthesis. Unlike the final API, which directly imparts therapeutic effects, intermediates are precursors that undergo further molecular modifications and purification. They are the backbone of multi-step organic synthesis, enabling chemists to gradually construct complex molecular structures with the desired precision for effective drug development. Without these carefully controlled intermediate steps, achieving the required purity and structural integrity of APIs would be significantly more challenging and costly.


The emphasis on the quality of pharmaceutical intermediates is paramount. Any deviation in purity, consistency, or composition at this foundational stage can have profound implications for the efficacy, safety, and regulatory compliance of the ultimate drug product. Contaminated or substandard intermediates can lead to ineffective medications, or worse, introduce harmful impurities that pose severe health risks to patients. Therefore, rigorous quality control measures, including advanced analytical testing techniques such as chromatography and spectroscopy, are critical throughout the production process. Adhering to stringent quality standards ensures that the final API meets global regulatory guidelines, facilitating smooth approval and market release.


Specifically, 1,4-Bis(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzene, as a boronic acid intermediate, is highly valued for its versatility in synthesizing a diverse range of pharmaceutical agents. It is particularly instrumental in the synthesis of chiral compounds, which are vital in modern pharmacology for enhancing therapeutic efficacy and minimizing side effects. Applications extend across various therapeutic areas, including the development of anti-inflammatory agents, anti-tumor drugs, and antiviral compounds. Its unique chemical properties allow for precise reactions, contributing significantly to the creation of advanced and targeted medications. The upstream products, Bis(pinacolato)diboron (CAS No.: 73183-34-3) and 1-Bromo-4-iodobenzene (CAS No.: 589-87-7), are key starting materials in its production, ensuring a robust and reliable supply chain.


The global pharmaceutical intermediates market continues to expand rapidly, driven by the increasing prevalence of chronic diseases and significant investments in research and development activities worldwide. Drug manufacturers are increasingly seeking reliable and specialized suppliers and manufacturers of intermediates to streamline their production processes, enhance efficiency, and reduce overall costs. This trend highlights the critical need for partners who not only offer high-quality products but also possess the expertise in tackling complex chemical synthesis projects and maintaining consistent supply.


As a leading manufacturer and supplier of advanced chemical compounds, NINGBO INNO PHARMCHEM CO.,LTD. is dedicated to providing superior pharmaceutical intermediates like 1,4-Bis(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzene (CAS NO: 99770-93-1). We understand the critical demand for these foundational materials in drug development. When you seek to buy or purchase such essential intermediates, you are investing in the very core of effective and safe medications. We are committed to offering competitive price points without compromising on the purity or consistency that is essential for your pharmaceutical synthesis processes. Our extensive experience in producing bulk, high-quality chemical products ensures that we can meet your demands, even offering free samples for evaluation. Our unwavering commitment is to empower global drug development by providing access to reliable, top-tier chemical building blocks, ensuring that patient health and treatment success remain at the forefront.

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NINGBO INNO PHARMCHEM CO.,LTD. was established in 2007. It is committed to the R&D, production and sales of raw materials, pharmaceutical intermediates and fine chemicals. We striving to create a high-efficiency and high-quality integrated chemical service platform to better serve domestic and foreign customers.

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