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In the dynamic realm of chemical synthesis, certain compounds stand out for their exceptional versatility and indispensable role in various scientific disciplines. Among these is 1H-Indazole-5-boronic Acid Pinacol Ester (CAS NO: 862723-42-0), a pivotal chemical intermediate that has garnered significant attention from researchers and industries worldwide. This unique boronic ester derivative is instrumental in facilitating complex organic transformations, making it a cornerstone for innovation in drug discovery, material science, and advanced chemical processes. NINGBO INNO PHARMCHEM CO.,LTD. proudly offers this high-quality compound, ensuring its availability for cutting-edge research and industrial applications.
Known by several synonyms, including 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole, 1H-Indazole-5-boronic Acid Pinacol Ester possesses the molecular formula C13H17BN2O2 and a molecular weight of approximately 244.10 g/mol. Typically appearing as an off-white to light yellow powder, its physical properties, such as a boiling point around 404.1±18.0 °C at 760 mmHg and a density of 1.2±0.1 g/cm³, contribute to its handling characteristics in laboratory and industrial settings. Purity is paramount for such intermediates, and the product supplied by NINGBO INNO PHARMCHEM CO.,LTD. consistently meets high standards, often exceeding 97% purity, thereby ensuring optimal reactivity and reliable results in demanding synthetic routes.
The primary utility of 1H-Indazole-5-boronic Acid Pinacol Ester lies in its exceptional reactivity as a building block in organic synthesis. It is particularly renowned for its critical role in the Suzuki-Miyaura cross-coupling reaction. This palladium-catalyzed reaction is a powerful tool for forming carbon-carbon bonds, enabling chemists to construct intricate molecular architectures with precision and efficiency. The pinacol ester form of the boronic acid enhances its stability and solubility, making it highly amenable to a wide range of reaction conditions and improving overall synthetic yields. Its ability to introduce diverse functional groups into target molecules makes it an invaluable asset for creating novel compounds with desired properties.
Beyond general organic synthesis, the applications of 1H-Indazole-5-boronic Acid Pinacol Ester extend significantly into medicinal chemistry. Researchers frequently employ it as a key intermediate in the development of novel therapeutic agents. Its structural features allow for the strategic modification of drug candidates, enhancing their biological activity, selectivity, and pharmacokinetic profiles. Promising areas include the synthesis of anti-cancer agents, where precise molecular design is crucial for efficacy, and neurobiology, where it contributes to the creation of compounds targeting neurological disorders. Furthermore, in material science, this compound is finding increasing use in the development of advanced materials, including specialized polymers and nanomaterials, due to its unique electronic properties and capacity to form stable complexes with metals.
The versatility of 1H-Indazole-5-boronic Acid Pinacol Ester is not limited to these fields alone. It also contributes to agricultural chemistry, playing a part in the synthesis of agrochemicals like herbicides and fungicides, which are essential for modern crop protection. In bioconjugation strategies, it serves to attach biomolecules to various surfaces or other molecules, thereby enhancing the delivery and targeting capabilities of therapeutic agents in biomedical applications. Its broad spectrum of utility underscores its importance as a high-value chemical building block for innovation across multiple industries.
NINGBO INNO PHARMCHEM CO.,LTD. is dedicated to being a reliable manufacturer and supplier of 1H-Indazole-5-boronic Acid Pinacol Ester. With stringent quality control measures and a commitment to customer satisfaction, we ensure that every batch of this crucial intermediate meets the highest industry standards. We understand the critical nature of timely and reliable supply for research and production schedules. For customers looking to buy 1H-Indazole-5-boronic Acid Pinacol Ester, NINGBO INNO PHARMCHEM CO.,LTD. offers competitive pricing and flexible packaging options to meet diverse needs. Whether you require a free sample for testing or bulk quantities for large-scale production, we are equipped to handle your requests. Our aim is to facilitate your research and development efforts, ensuring a seamless purchase experience for this essential chemical. Please do not hesitate to inquire about the current price and availability for your next purchase of this versatile compound.
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A: We don't have Minimum Order Quantity, exact quantity should be provided before quotation for us to calculate the exact cost.
A: We don't provide free samples due to lots of request and expensive international courier's cost, we can deduct the sample charge after commercial order placed.
A: Our payment terms: Small or sample order: T/T IN ADVANCE. Commercial order: First order should be by T/T IN ADVANCE or L/C at sight, and following orders T/T 30~90days is acceptable subject to approval of credit application.
