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2,3-Dichloro-4-nitroaniline (CAS 69951-03-7): A Versatile Pharmaceutical Intermediate

2,3-Dichloro-4-nitroaniline (CAS 69951-03-7) stands as a crucial organic compound with significant utility across various industrial sectors. Characterized by its chemical formula C6H4Cl2N2O2 and a molecular weight of approximately 207.01 g/mol, this compound is readily identified by its CAS number 69951-03-7. Its structure, featuring a benzene ring substituted with two chlorine atoms, a nitro group, and an amino group, grants it a unique reactivity profile, making it an indispensable building block in complex chemical syntheses.


As a fine white crystalline powder, 2,3-Dichloro-4-nitroaniline exhibits remarkable purity, typically reaching a minimum of 99%. Its physical properties include a boiling point around 367.4 ± 37.0 °C at 760 mmHg and a density of approximately 1.6 g/cm3. These stable characteristics ensure its reliability and consistent performance in demanding applications, particularly within specialized chemical processes. The meticulous control over its synthesis ensures that each batch meets stringent quality standards, providing a dependable raw material for further chemical transformations.


The primary application of 2,3-Dichloro-4-nitroaniline is its role as a pharmaceutical intermediate. Its distinctive chemical structure enables its incorporation into the synthesis pathways of various active pharmaceutical ingredients (APIs) and other medicinal compounds. This makes it a foundational component for drug discovery and development, supporting the creation of novel therapeutic agents. Beyond pharmaceuticals, its versatility extends to the agrochemical industry, where it can be utilized in the formulation of pesticides or herbicides, contributing to modern agricultural solutions. Furthermore, its chemical properties make it a candidate for the synthesis of certain dyes and pigments, offering color solutions across different manufacturing processes.


The synthesis of 2,3-Dichloro-4-nitroaniline typically involves a well-established two-step process. The initial stage comprises the nitration of 2,3-dichloroaniline, utilizing a carefully controlled mixture of concentrated nitric acid and sulfuric acid. This step requires precise conditions to ensure optimal nitration without over-reaction. Following nitration, an ammonolysis reaction is performed, often under high-temperature conditions in an organic solvent with ammoniacal liquor, to yield the desired compound. This synthetic route is valued for its efficiency and capability to achieve high yields, ensuring scalable production to meet industrial demands.


Ensuring the highest quality of 2,3-Dichloro-4-nitroaniline is paramount for its intended applications. Comprehensive quality control measures are employed, including rigorous testing methods such as H-NMR and Mass spectroscopy for identification, alongside HPLC or GC for purity verification and impurity profiling. These tests confirm the chemical's integrity and consistent high-purity levels. As a leading manufacturer and supplier of advanced chemical intermediates, we are committed to delivering products that exceed industry benchmarks for quality and reliability. Our extensive expertise in custom chemical synthesis allows us to provide this compound in various quantities, from gram-scale research samples to bulk industrial supplies.


For those looking to buy 2,3-Dichloro-4-nitroaniline or initiate a purchase, we offer flexible packaging options including 25g, 100g, 500g, and larger bulk packages to accommodate diverse project requirements. Detailed product specifications and certificates of analysis are readily available upon request, ensuring complete transparency and confidence in your procurement. We strive to provide competitive price structures while maintaining superior product quality and efficient logistics. Whether you require this essential intermediate for ongoing research, development projects, or large-scale manufacturing, our team is equipped to support your needs with prompt service and expert technical assistance. Contact us today to learn more about availability and pricing for your specific requirements.

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