2',3'-Dideoxyguanosine (ddG), a pivotal nucleoside analog identified by CAS.NO: 85326-06-3, stands as a cornerstone in modern biomedical research and pharmaceutical development. Its unique molecular structure, characterized by the absence of hydroxyl groups at the 2' and 3' positions of the ribose sugar, grants it distinctive properties that are highly advantageous in various scientific disciplines. This white to off-white powder, with a molecular formula of C10H13N5O3 and a molecular weight of 251.24200, consistently demonstrates high purity, typically at 98.0% or greater by HPLC analysis, ensuring reliable performance in demanding applications.

The primary mechanism of action for 2',3'-Dideoxyguanosine lies in its ability to act as a chain terminator during nucleic acid synthesis. Unlike natural deoxyribonucleotides, ddG lacks the necessary 3'-hydroxyl group required for phosphodiester bond formation, effectively halting the elongation of DNA or RNA strands by polymerases. This crucial characteristic makes it an invaluable tool for understanding enzyme kinetics and for developing inhibitors of nucleic acid replication.

The applications of 2',3'-Dideoxyguanosine are remarkably diverse, spanning from fundamental biochemical studies to advanced therapeutic strategies. In the realm of antiviral research, ddG and its derivatives have been extensively investigated for their potency against a range of viral pathogens, including HIV and hepatitis viruses. By interfering with viral reverse transcriptase and other polymerases, it effectively disrupts the viral life cycle, positioning it as a critical component in the development of new antiviral agents.

Beyond its antiviral utility, ddG plays a significant role in various biotechnology applications. It is frequently employed in techniques such as DNA sequencing (Sanger method), where its chain-terminating properties are essential for generating fragments of varying lengths, enabling sequence determination. Researchers also utilize 2',3'-Dideoxyguanosine in enzyme mechanistic studies to elucidate the precise functions of polymerases and other nucleic acid-modifying enzymes. Furthermore, its ability to produce RNA and DNA sequences that cannot be further extended by polymerases or joined by DNA ligases is vital for specific molecular biology experiments, including pyrophosphorolysis-activated polymerization (PAP) for the detection of rare mutations.

Emerging research also highlights the potential of 2',3'-Dideoxyguanosine in anticancer therapy. Its capacity to inhibit cellular nucleic acid synthesis shows promise in suppressing the proliferation of rapidly dividing tumor cells, offering a potential pathway for novel cancer treatments with potentially reduced side effects compared to traditional chemotherapy. Its versatility also extends to gene therapy applications, where modified nucleosides are crucial for targeted gene editing and the development of treatments for genetic disorders. In diagnostic tools, ddG is incorporated into assays for detecting viral infections and genetic mutations, contributing significantly to personalized medicine.

As a leading manufacturer and trusted supplier of high-quality chemical compounds, our commitment lies in providing 2',3'-Dideoxyguanosine that meets the stringent requirements of pharmaceutical and research industries. Our dedication to quality assurance ensures that every batch offers exceptional purity and consistent performance. For those looking to buy 2',3'-Dideoxyguanosine, we offer competitive price options and reliable supply chain solutions. Whether you need a bulk purchase or smaller quantities for specialized research, we strive to be your preferred partner. Inquiries regarding product specifications, current stock, or how to purchase this essential nucleoside analog are welcome.