For professionals in the chemical and pharmaceutical sectors, a deep understanding of the raw materials they utilize is fundamental. 2,3-Difluorophenylboronic acid (CAS: 121219-16-7) is a prime example of a sophisticated intermediate whose properties and manufacturing process directly impact its utility. This article provides insights into its key characteristics, specifications, and what buyers should look for when they intend to buy it.

Chemical Identity and Properties

2,3-Difluorophenylboronic acid is an organoboron compound with the molecular formula C6H5BF2O2 and a molecular weight of approximately 157.91 g/mol. Its structure features a phenyl ring substituted with two fluorine atoms at the ortho and meta positions, and a boronic acid group (-B(OH)2). This unique substitution pattern dictates its reactivity and potential applications.

Key properties often highlighted by manufacturers include:

• Appearance: Typically presented as a white powder, which is a standard form for many solid chemical intermediates.
• Assay: A minimum purity of ≥98.0% is commonly specified, ensuring its suitability for demanding synthesis tasks. Higher purity grades may be available for specialized applications.
• Melting Point: It typically has a melting point around 95 °C (with decomposition), a characteristic that guides handling and processing.
• Solubility: While specific data might vary, boronic acids generally show solubility in polar organic solvents.

Manufacturing Considerations

The synthesis of 2,3-Difluorophenylboronic acid involves multi-step chemical processes that require precise control over reaction conditions to ensure high yield and purity. Common synthetic routes might involve:

• Halogenation and Lithiation: Starting from appropriately substituted fluorobenzene derivatives.
• Boronation: Reacting an organometallic intermediate (like a Grignard or organolithium reagent) with a borate ester, followed by acidic hydrolysis to yield the boronic acid.

Reputable manufacturers in China and globally invest in advanced manufacturing technologies and stringent quality control measures to consistently produce this intermediate. When you are looking to purchase this material, inquiring about the manufacturing process and quality assurance protocols from your potential supplier can provide confidence in the product's reliability.

Sourcing and Pricing Information

For procurement managers, understanding the market dynamics and obtaining accurate price information is crucial. The cost of 2,3-Difluorophenylboronic acid can depend on factors such as order volume, purity requirements, and global supply-demand trends. Engaging with multiple suppliers for quotes is a standard practice.

In conclusion, 2,3-Difluorophenylboronic acid is a vital intermediate characterized by its specific fluorine substitution and high purity. Understanding its properties and the manufacturing expertise behind its production is key for anyone looking to procure this essential chemical building block for their advanced synthesis needs.