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2-Acetylbenzimidazole: A Key Intermediate for Thiabendazole and Beyond

2-Acetylbenzimidazole, identified by its Chemical Abstracts Service (CAS) number 18773-95-0, stands as a pivotal chemical compound in various industrial and pharmaceutical applications. Also known by its systematic name 1-(1H-1,3-Benzimidazol-2-yl)-1-ethanone, this compound is a versatile building block, highly valued for its unique chemical structure and reactivity. NINGBO INNO PHARMCHEM CO.,LTD. is proud to offer high-quality 2-Acetylbenzimidazole, ensuring reliable supply for diverse industry needs. Its widespread use underscores its significance in modern chemical synthesis.


Characterized by the molecular formula C9H8N2O and a molecular weight of 160.17300, 2-Acetylbenzimidazole presents as a white powder. Its critical physical and chemical properties include a density of 1.265 g/cm3, a boiling point of 347.402ºC at 760 mmHg, and a flash point of 167.988ºC. These precise specifications are crucial for ensuring the compound's performance and stability in various chemical processes. Our commitment at NINGBO INNO PHARMCHEM CO.,LTD. is to provide material that consistently meets an assay of ≥98.0% purity, guaranteeing optimal results for our clients.


The primary and perhaps most critical application of 2-Acetylbenzimidazole is its role as a key intermediate in the synthesis of Thiabendazole (CAS: 148-79-8). Thiabendazole is a widely recognized and effective fungicide, extensively used in agriculture to protect crops from various fungal diseases, as well as in veterinary medicine and human health for its broad-spectrum antimicrobial properties. The efficient production of Thiabendazole relies heavily on the consistent quality and availability of 2-Acetylbenzimidazole as its precursor, highlighting the compound's indispensable role in the agricultural and pharmaceutical sectors.


Beyond its direct link to Thiabendazole, 2-Acetylbenzimidazole serves as a highly valuable synthon for the synthesis of a broad range of biologically active molecules, particularly benzimidazolyl chalcones. Research demonstrates that derivatives synthesized from 2-Acetylbenzimidazole exhibit diverse and significant pharmacological activities. These include potent antibacterial and antifungal properties, making them promising candidates for new antimicrobial agents. Furthermore, these derivatives have shown efficacy in areas such as anticancer, anti-inflammatory, antitubercular, and analgesic applications. Its versatility extends to central nervous system activities and even anthelmintic and insect anti-feedant properties, illustrating its broad utility in medicinal chemistry and drug discovery. The ease with which 2-Acetylbenzimidazole can be transformed into complex, multi-functional compounds positions it as a cornerstone in the development of next-generation pharmaceuticals.


The synthesis of 2-Acetylbenzimidazole can be achieved through various established chemical routes. One common method involves the oxidation of 2-(α-hydroxyethyl)benzimidazole. Another effective approach includes the condensation of 2-acetylbenzimidazole with specific aromatic aldehydes, which further leads to the formation of benzimidazolyl chalcones. NINGBO INNO PHARMCHEM CO.,LTD. employs advanced synthetic methodologies and stringent quality control measures to ensure the consistent production of 2-Acetylbenzimidazole that meets the highest industry standards for purity and performance.


As a leading manufacturer and supplier, NINGBO INNO PHARMCHEM CO.,LTD. adheres to rigorous quality management systems throughout the production process. Our 2-Acetylbenzimidazole is carefully packed in 25 kg drums, with custom packaging options also available to meet specific customer requirements. Proper storage in a cool, ventilated place is recommended to maintain its integrity and shelf life. For competitive price information or to buy 2-Acetylbenzimidazole, our team is ready to assist with your bulk purchase needs. We are dedicated to providing seamless service and ensuring that our customers receive a product of unmatched quality and reliability.


In conclusion, 2-Acetylbenzimidazole is an indispensable chemical intermediate with far-reaching applications, from its crucial role in fungicide production to its significant contribution to the synthesis of diverse pharmaceutical compounds. NINGBO INNO PHARMCHEM CO.,LTD. remains committed to being a trusted partner, offering superior quality 2-Acetylbenzimidazole supported by exceptional service and technical expertise. We invite you to explore the potential of this versatile compound with us.

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NINGBO INNO PHARMCHEM CO.,LTD. was established in 2007. It is committed to the R&D, production and sales of raw materials, pharmaceutical intermediates and fine chemicals. We striving to create a high-efficiency and high-quality integrated chemical service platform to better serve domestic and foreign customers.

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