Understanding the fundamental chemical properties of a compound is crucial for any researcher or industry professional looking to utilize it effectively. 2-Amino-4-methylpyrimidine (CAS 108-52-1) is a compound that warrants close examination due to its broad applicability, particularly within the pharmaceutical and fine chemical sectors. This article serves as a guide to its key chemical characteristics and its diverse industrial applications, offering insights for those seeking to purchase or research this valuable intermediate.

Chemical Profile of 2-Amino-4-methylpyrimidine

2-Amino-4-methylpyrimidine, with the molecular formula C5H7N3 and a molecular weight of 109.13 g/mol, is a heterocyclic aromatic organic compound. Its defining features include a pyrimidine ring substituted with an amino group at the 2-position and a methyl group at the 4-position. These functional groups dictate its chemical behavior and reactivity.

Key chemical properties include:

• Appearance: Typically described as an Off-white to light brown Crystalline Powder.
• Melting Point: Reported in literature as approximately 158-160 °C, indicating its solid state at room temperature and offering a benchmark for purity.
• Solubility: While specific solubility data might vary, heterocyclic amines of this nature generally exhibit some solubility in polar organic solvents and may have limited solubility in water, depending on pH.
• pKa: A pKa value of 4.11 (+1) at 20°C indicates its basic character due to the nitrogen atoms in the ring and the exocyclic amino group.

These properties are essential for chemists when planning synthesis routes, determining reaction conditions, and assessing the compound's stability and handling requirements.

Industrial Applications of 2-Amino-4-methylpyrimidine

The versatility of 2-Amino-4-methylpyrimidine stems from its potential to act as a building block for more complex molecules. Its primary industrial applications include:

• Pharmaceutical Intermediates: This is arguably its most significant use. It serves as a key intermediate in the synthesis of various Active Pharmaceutical Ingredients (APIs). The pyrimidine scaffold is a common structural motif in many drugs, including those used for treating cancer, viral infections, and neurological conditions. Researchers rely on its availability from trusted chemical suppliers to advance drug discovery programs.
• Diagnostic Reagents: In the field of diagnostics, 2-Amino-4-methylpyrimidine can be incorporated into the synthesis of molecules used in diagnostic assays and kits. Its chemical structure can be modified to create probes or markers for specific biological targets, contributing to advancements in medical diagnostics.
• Fine Chemical Synthesis: Beyond pharmaceuticals, it finds application in broader fine chemical synthesis, where its reactive functional groups can be utilized to create a range of specialized organic compounds for various industrial purposes.

Sourcing and Procurement Considerations

For any industrial application, securing a reliable source of 2-Amino-4-methylpyrimidine is paramount. Companies looking to purchase this compound should look for manufacturers that provide detailed specifications, consistent product quality, and timely delivery. Understanding the pricing structure and minimum order quantities is also essential for effective procurement. If you are looking to buy this chemical or inquire about its pricing, contacting a reputable manufacturer or chemical supplier in China can provide access to high-quality material backed by professional service.

In essence, 2-Amino-4-methylpyrimidine is a compound with well-defined chemical properties that underpin its broad utility in critical industrial sectors. Its role as a pharmaceutical intermediate and a component in diagnostic reagents highlights its importance in scientific advancement and product development.