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In the realm of fine chemicals, 2-Bromo-1,3-benzothiazole (CAS 2516-40-7) emerges as a pivotal compound, recognized for its utility in advanced chemical synthesis. This article explores its fundamental properties, common preparation methods, and the wide array of applications that make it a valuable commodity for researchers and industrial chemists. As a leading manufacturer of specialty chemicals, we are committed to providing high-quality 2-Bromo-1,3-benzothiazole to meet the dynamic needs of the global market.
Chemically, 2-Bromo-1,3-benzothiazole is characterized by its heterocyclic structure, featuring a benzene ring fused with a thiazole ring, with a bromine atom at the 2-position. Its molecular formula is C7H4BrNS, and it has a molecular weight of 214.08 g/mol. Typically appearing as a pale yellow to white solid, it possesses a melting point range of 39-43°C. While slightly soluble in water, it readily dissolves in many organic solvents, facilitating its use in various reaction mediums. The presence of the bromine atom makes it an excellent substrate for nucleophilic substitution and cross-coupling reactions, such as Suzuki, Heck, and Sonogashira couplings, which are fundamental in modern organic synthesis.
The synthesis of 2-Bromo-1,3-benzothiazole can be achieved through several routes. A common method involves the bromination of benzothiazole using brominating agents in suitable solvents. For instance, reactions involving N-bromosuccinimide (NBS) or elemental bromine under controlled conditions can yield the desired product. Industrial-scale production prioritizes efficiency, yield, and purity, often employing optimized reaction conditions and purification techniques to ensure a consistent product for customers looking to purchase.
The primary application of 2-Bromo-1,3-benzothiazole is as a pharmaceutical intermediate. It serves as a crucial building block in the synthesis of various APIs, contributing to the development of therapeutic agents across different disease areas. Its versatility also extends to the agrochemical sector and the production of specialized dyes. For R&D scientists and procurement professionals seeking this compound, understanding its availability from reliable suppliers, competitive price points, and technical specifications is key. Partnering with a reputable supplier ensures access to a product that meets rigorous quality standards, thereby supporting successful research and manufacturing outcomes.
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