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2-Bromo-5-fluorobenzonitrile: Key Intermediate in Organic Synthesis

2-Bromo-5-fluorobenzonitrile, identified by its CAS Registry Number 57381-39-2, stands as a crucial chemical compound widely recognized for its pivotal role as an intermediate in organic synthesis. This compound, also known by synonyms such as 2-bromo-5-fluoro-benzonitrile, is highly valued for its unique molecular structure and reactivity, making it indispensable in the creation of a wide array of advanced chemical products.


Chemically, 2-Bromo-5-fluorobenzonitrile possesses the molecular formula C7H3BrFN and a molecular weight of approximately 200.008 g/mol. It is typically presented as a white crystalline powder, a characteristic appearance that signifies its purity and quality. The compound exhibits distinct physical and chemical properties vital for its industrial applications. Its density is approximately 1.7±0.1 g/cm3, indicating a relatively dense solid. The melting point is observed within the range of 92-95 °C, which is a key parameter for its handling and storage. Furthermore, it has a boiling point of 251.2±25.0 °C at 760 mmHg and a flash point of 105.7±23.2 °C, necessitating proper safety protocols during its use. The vapor pressure is remarkably low, at 0.0±0.5 mmHg at 25°C, and its index of refraction is 1.578.


The specification for 2-Bromo-5-fluorobenzonitrile emphasizes its high quality. Typically, the assay is guaranteed to be ≥98.0%, ensuring its efficacy and reliability for sensitive synthetic processes. This high purity level is critical for applications where precise chemical reactions are required, minimizing impurities that could compromise the final product's quality.


The primary application of 2-Bromo-5-fluorobenzonitrile lies in its function as an intermediate for organic synthesis. This means it serves as a building block in the multi-step creation of more complex organic molecules. Its bromine and fluorine substituents, along with the nitrile group, offer versatile reaction sites, enabling chemists to synthesize a diverse range of compounds. These advanced compounds can find applications in various sectors, including pharmaceuticals, agrochemicals, and specialized materials science, contributing to the development of new drugs, crop protection agents, and high-performance polymers.


For optimal preservation of its quality and integrity, 2-Bromo-5-fluorobenzonitrile should be stored in a cool, ventilated place, away from direct sunlight and sources of heat or ignition. Adherence to these storage guidelines helps maintain its chemical stability and prevents degradation. Regarding packaging, the product is typically supplied in 25 kg drums, with the flexibility to customize packaging according to specific customer requirements, catering to diverse logistical and operational needs.


As a leading manufacturer and supplier of high-quality chemical intermediates, NINGBO INNO PHARMCHEM CO.,LTD. is committed to providing premium 2-Bromo-5-fluorobenzonitrile to clients worldwide. We ensure rigorous quality control and adherence to international standards in every batch. For those looking to buy or purchase this essential chemical, we offer competitive price options and flexible supply solutions. We invite you to contact us for detailed inquiries, to request a quotation, or to discuss your specific requirements. Our team is dedicated to supporting your synthetic endeavors with reliable products and exceptional service.

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NINGBO INNO PHARMCHEM CO.,LTD. was established in 2007. It is committed to the R&D, production and sales of raw materials, pharmaceutical intermediates and fine chemicals. We striving to create a high-efficiency and high-quality integrated chemical service platform to better serve domestic and foreign customers.

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