2-Bromo-5-fluorobenzotrifluoride (CAS 40161-55-5) stands as a pivotal organic compound, recognized for its unique molecular structure featuring both bromine and fluorine atoms on a trifluoromethylated benzene ring. With the molecular formula C7H3BrF4 and a molecular weight of 242.99600 g/mol, this compound is highly valued across various chemical industries, particularly in pharmaceutical development and advanced organic synthesis. NINGBO INNO PHARMCHEM CO.,LTD. is a dedicated manufacturer committed to providing this versatile chemical with exceptional purity and consistent quality.

As a colorless liquid, 2-Bromo-5-fluorobenzotrifluoride exhibits a density of approximately 1.695 g/mL at 25 °C, a boiling point ranging from 136-143°C, and a flash point of 65.4°C (or 147°F). Its refractive index is about 1.465. These well-defined physical and chemical properties ensure its reliability and predictability in complex synthetic pathways. The compound also boasts good solubility in various organic solvents, further enhancing its utility as a chemical reagent.

The primary application of 2-Bromo-5-fluorobenzotrifluoride lies in its role as a crucial pharmaceutical intermediate. Its reactive bromine group and a strategically positioned fluorine atom make it an indispensable building block for the synthesis of more intricate and biologically active molecules. The bromine atom can be readily substituted through various reactions, while the fluorine atom significantly influences the final product's reactivity, lipophilicity, and overall properties. A notable application involves its use as an intermediate in the multi-step synthesis of advanced pharmaceutical compounds, such as HSD-016. HSD-016 is significant in the development of drugs for treating conditions like type 2 diabetes, by inhibiting 11β-hydroxysteroid dehydrogenase (11β-HSD1), which converts cortisone into cortisol. Beyond pharmaceuticals, it serves as a valuable tool in the study of fluorine chemistry, allowing researchers to explore the profound impact of fluorine incorporation on molecular characteristics.

NINGBO INNO PHARMCHEM CO.,LTD. ensures the production of 2-Bromo-5-fluorobenzotrifluoride with a guaranteed purity of ≥98.0%. The synthesis typically involves a rigorous multi-step process, beginning with the nitration of m-fluorobenzotrifluoride to yield 5-fluoro-2-nitrobenzotrifluoride. This is followed by a reduction of the nitro group to an amino group, often through catalytic hydrogenation, and finally, bromination via diazotization using cuprous bromide and hydrobromic acid. This meticulous approach guarantees a product of high purity and consistent yield, essential for sensitive downstream applications.

While a powerful chemical tool, 2-Bromo-5-fluorobenzotrifluoride requires careful handling. It is classified as an irritant, potentially causing skin, eye, and respiratory irritation. Aromatic halides can exhibit toxicity upon inhalation, ingestion, or skin contact, and the presence of fluorine can render it corrosive. NINGBO INNO PHARMCHEM CO.,LTD. adheres to stringent safety protocols and provides comprehensive safety data sheets to ensure safe handling and storage, typically in tightly closed containers in cool, dry conditions.

As a leading supplier and manufacturer of high-quality 2-Bromo-5-fluorobenzotrifluoride, NINGBO INNO PHARMCHEM CO.,LTD. is dedicated to meeting the diverse needs of the global chemical and pharmaceutical industries. For inquiries regarding price, bulk purchase, or specific product specifications, we encourage interested parties to reach out directly. Our commitment to quality, reliable supply, and customer satisfaction makes us a preferred partner for your chemical sourcing needs. We offer flexible packing options, including fluorinated bottles and drums, tailored to your requirements.