In the realm of fine chemicals, 2-Chloro-3-fluorobenzaldehyde stands out as a particularly valuable intermediate. Its unique molecular structure, featuring both chlorine and fluorine substituents on a benzaldehyde core, imparts specific reactivity that is highly sought after in complex organic synthesis. This article delves into the key properties and the diverse synthesis applications that make 2-Chloro-3-fluorobenzaldehyde (CAS 96516-31-3) indispensable for researchers and industrial chemists.

Understanding the Chemical Profile

2-Chloro-3-fluorobenzaldehyde is typically characterized as an off-white to pale yellow solid. Its molecular formula is C7H4ClFO, with a molecular weight of 158.56 g/mol. Key physical properties include a melting point typically between 29-32°C and a boiling point around 211°C at atmospheric pressure. Its density is approximately 1.352 g/cm³. A flash point of around 81.4°C indicates moderate flammability, necessitating appropriate handling and storage in a cool, ventilated place, ideally under an inert atmosphere. For procurement, ensuring a high purity level, often specified as ≥99.0% by HPLC, is crucial for predictable reaction outcomes.

Versatile Synthesis Applications

The reactivity of the aldehyde group, combined with the electronic effects of the halogen substituents, makes 2-Chloro-3-fluorobenzaldehyde a versatile building block. Its primary use lies as an intermediate in the synthesis of more complex organic molecules, particularly within the pharmaceutical and agrochemical industries. For example, it can be utilized in Wittig reactions, Grignard additions, and various condensation reactions to introduce the 2-chloro-3-fluorophenyl moiety into target compounds.

Researchers often buy this compound for the synthesis of novel drug candidates, where the specific placement of halogens can influence pharmacokinetic properties and biological activity. Similarly, in agrochemical research, it is employed to develop new pesticides, herbicides, and fungicides with enhanced efficacy and environmental profiles. When you purchase from a reliable manufacturer, you are guaranteed the quality needed for these advanced applications.

Sourcing and Availability

For companies looking to buy 2-Chloro-3-fluorobenzaldehyde, it is essential to partner with reputable suppliers and manufacturers. These suppliers can provide the necessary technical data, safety information (SDS), and ensure consistent product quality. Investigating manufacturers in regions with established chemical production capabilities, such as China, often yields competitive pricing and reliable supply chains. When inquiring about price, consider the volume and purity required.

In summary, 2-Chloro-3-fluorobenzaldehyde is a critical intermediate for innovation in chemistry. Its well-defined properties and broad utility in synthesizing specialized molecules underscore its importance. By understanding its profile and partnering with trusted suppliers, researchers and manufacturers can effectively leverage this compound for their synthetic endeavors.