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In the realm of organic chemistry, the precise understanding of a compound's properties is fundamental to its effective utilization. 2-Chloro-3-fluoropyridine (CAS 17282-04-1) is one such compound, widely recognized as a critical intermediate, especially within the pharmaceutical sector. For researchers and manufacturers aiming to leverage its capabilities, a deep dive into its chemical and physical characteristics is essential. This article highlights the key properties that make 2-Chloro-3-fluoropyridine a sought-after building block, and where to procure it reliably.
As a heterocyclic compound, 2-Chloro-3-fluoropyridine presents a unique combination of functional groups. Its molecular formula, C5H3ClFN, and molecular weight of approximately 131.54 g/mol, are foundational to its reactivity. The presence of both chlorine and fluorine atoms on the pyridine ring imparts specific electronic and steric properties, facilitating targeted chemical reactions such as nucleophilic substitution and various cross-coupling methodologies. This structural advantage is why many pharmaceutical companies seek out reliable suppliers of this compound for their API synthesis pipelines.
Key physical properties that influence handling and application include its appearance: a colorless to pale yellow liquid. Its density is around 1.3±0.1 g/cm³, indicating a relatively dense substance. The boiling point is approximately 151.6±20.0 °C at 760 mmHg, suggesting it can withstand moderate heating during reaction processes. The flash point, noted at 45.5±21.8 °C, signifies a degree of flammability that requires appropriate safety precautions during storage and use, a detail that any responsible manufacturer will provide clear guidance on. The refractive index, measured at 1.503, is another characteristic property useful for identification and quality control.
For those looking to purchase 2-Chloro-3-fluoropyridine, understanding these properties helps in selecting the right grade and ensuring successful integration into synthesis protocols. The compound's stability, coupled with its reactive sites, makes it an efficient intermediate for building complex molecular structures. When you buy this chemical, ensure your chosen supplier can provide detailed technical specifications and safety documentation to support your operations. High purity, often exceeding ≥98.0%, is typically required for pharmaceutical applications, a standard that reputable suppliers diligently maintain.
In conclusion, the chemical and physical properties of 2-Chloro-3-fluoropyridine underscore its value in advanced organic synthesis. Its role as a pharmaceutical intermediate is well-established, and sourcing it from a dependable 2-Chloro-3-fluoropyridine manufacturer in China or a global distributor ensures quality and accessibility, driving innovation in drug discovery and chemical manufacturing.
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