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The Role of 2-Cyano-5-hydroxypyridine as a Nitrile Building Block in Medicinal Chemistry

Nitrile functional groups are integral to a multitude of pharmacologically active compounds, making them indispensable in medicinal chemistry. These groups contribute significantly to a molecule's physicochemical properties, including lipophilicity, metabolic stability, and enzyme inhibition. Among the essential scaffolds that incorporate this key functionality, 2-Cyano-5-hydroxypyridine (CAS 86869-14-9) emerges as a powerful nitrile building block.


This compound offers a unique combination of a pyridine ring, a hydroxyl group, and a nitrile group, providing diverse opportunities for chemical modifications and molecular diversification. In drug design, the ability to selectively introduce or transform these functional groups is paramount for optimizing drug candidates. The nitrile group, in particular, can be converted into various other functional groups, such as carboxylic acids, amides, or tetrazoles, which are common bioisosteres in medicinal chemistry. This versatility makes 2-Cyano-5-hydroxypyridine an invaluable asset for synthetic chemists.


The purity of chemical building blocks is a non-negotiable factor in medicinal chemistry. Even trace impurities can lead to inconsistent experimental results, complicate purification processes, and ultimately delay drug discovery timelines. When you purchase 86869-14-9 intermediate, ensuring its high quality is critical for reliable and reproducible synthetic steps. NINGBO INNO PHARMCHEM CO.,LTD. is dedicated to providing high purity 2-Cyano-5-hydroxypyridine, meeting the stringent demands of pharmaceutical research and development.


Researchers looking to synthesize novel compounds for disease treatment will find 2-Cyano-5-hydroxypyridine an excellent starting material. Its incorporation into complex molecular structures allows for the creation of compounds with enhanced binding affinities and improved pharmacological profiles. As a dependable 2-Cyano-5-hydroxypyridine CAS 86869-14-9 supplier, NINGBO INNO PHARMCHEM CO.,LTD. ensures consistent availability and superior product integrity, supporting your innovative projects from conception to optimization.


From initial lead generation to late-stage development, the strategic use of versatile nitrile building blocks like 2-Cyano-5-hydroxypyridine accelerates the pace of medicinal chemistry. Our commitment as a leading high purity 2-Cyano-5-hydroxypyridine manufacturer is to empower scientists with the essential chemical tools needed to make significant strides in developing the next generation of life-saving medicines.

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