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2-Fluoro-N-methylaniline: Key Intermediate for Pharmaceutical Synthesis

2-Fluoro-N-methylaniline, identified by its CAS number 1978-38-7, stands as a pivotal organic compound in various chemical synthesis processes. Also known by its synonyms such as N-methyl-o-fluoroaniline or n-methyl-2-fluoroaniline, this aniline derivative holds a significant position due to its unique molecular structure, C7H8FN, and a molecular weight of 125.14400. Its versatility makes it an indispensable building block for advanced chemical research and industrial applications.


The physical and chemical characteristics of 2-Fluoro-N-methylaniline are well-defined, ensuring its reliable use in precise syntheses. It typically presents as a yellow clear liquid, though variations from colorless to light yellow clear liquid are also observed. Key properties include a density of approximately 1.106 g/ml and a boiling point ranging from 87-88ºC at 20mm Hg. The flash point is noted at 62.9ºC, highlighting specific handling requirements. Furthermore, it exhibits slight solubility in common organic solvents like chloroform and methanol, which is crucial for its integration into various reaction systems. Its refractive index is within the range of 1.5340-1.5390, contributing to its distinct chemical profile.


Quality assurance is paramount for 2-Fluoro-N-methylaniline, especially given its role as an intermediate. High-grade material typically boasts an assay of ≥99.0% purity, with a moisture content maintained at ≤0.2%. Such stringent specifications ensure optimal performance and minimal impurities in subsequent reactions. Proper storage is essential to preserve its integrity; it should be kept in a cool, well-ventilated, and dark place under an inert atmosphere, ideally at room temperature. Containers must be securely sealed to prevent leaks and maintain product stability over time. Standard packaging often involves 200 kg drums, with flexibility for custom packaging solutions tailored to specific customer requirements.


The primary application of 2-Fluoro-N-methylaniline lies in its utility as an organic synthesis intermediate. It is particularly valued in the preparation of a diverse range of complex organic compounds. A notable application includes its use in the synthesis of various pharmaceutical compounds, such as muscarinic agonists, demonstrating its critical role in drug discovery and development. Its fluorine atom and methylamino group provide unique reactivity, making it a key component for creating novel chemical entities with specific biological activities. This makes it a sought-after chemical in the pharmaceutical and fine chemical industries.


For research institutions and chemical industries seeking to procure this essential compound, sourcing from a reliable partner is crucial. When considering where to buy 2-Fluoro-N-methylaniline, prospective clients should prioritize a reputable manufacturer and supplier capable of consistently delivering high-purity material. Enquiries regarding the current price and available quantities can be made directly to facilitate a seamless purchase. Ensuring a secure and stable supply chain for this vital intermediate is key to supporting continuous progress in organic synthesis and pharmaceutical innovation.

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