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2-Naphthoyl Chloride: A Versatile Intermediate for Chemical Synthesis

2-Naphthoyl Chloride (CAS: 2243-83-6) is a highly reactive acyl chloride derivative that plays a pivotal role as a key intermediate in various organic synthesis processes. With its molecular formula C11H7ClO and a molecular weight of 190.63 g/mol, this compound is indispensable for industries ranging from pharmaceuticals to agrochemicals and specialty chemical manufacturing. Its distinctive chemical structure allows for efficient acylation reactions, making it a cornerstone for synthesizing a wide array of valuable compounds.


Typically appearing as a white to light yellow crystalline solid, 2-Naphthoyl Chloride possesses specific physical properties that define its handling and application. It exhibits a melting point generally in the range of 49-52°C and a boiling point around 160-162°C (at 11 mmHg). While it readily decomposes in water, it shows good solubility in organic solvents like DMSO and acetone, which facilitates its use in various reaction media. Proper storage under inert gas and moisture-free conditions is crucial due to its sensitivity to moisture, which can lead to decomposition.


The versatility of 2-Naphthoyl Chloride is evident in its extensive range of applications. In the pharmaceutical industry, it serves as a vital precursor for the synthesis of complex active pharmaceutical ingredients (APIs), including compounds with potential anti-inflammatory and anticancer properties. Its reactivity is leveraged to build intricate molecular structures necessary for drug development. Furthermore, it is widely utilized in the production of agrochemicals, contributing to the creation of effective pesticides, herbicides, and other agricultural inputs that support global food production.


Beyond pharmaceuticals and agrochemicals, 2-Naphthoyl Chloride finds significant applications in the manufacturing of specialty chemicals. It is an essential building block for synthesizing various amides, esters, and ketones through efficient acylation reactions. This makes it valuable in the dye industry for producing vibrant and durable colorants, as well as in polymer chemistry, where it is used for modifying functional materials to enhance their properties. Its corrosive nature necessitates careful handling, including the use of appropriate personal protective equipment to avoid skin and eye irritation.


At NINGBO INNO PHARMCHEM CO.,LTD., we understand the critical importance of high-purity chemical intermediates for industrial success. As a dedicated manufacturer and supplier of 2-Naphthoyl Chloride, we are committed to providing products that meet rigorous quality standards. Our advanced production processes ensure consistent purity and reliability, making us a preferred partner for companies worldwide. We strive to offer competitive price options for bulk and specialized orders, facilitating seamless purchase processes for our clients. Whether you are looking to buy small quantities for research or require large volumes for industrial production, NINGBO INNO PHARMCHEM CO.,LTD. is equipped to meet your needs with efficiency and professionalism.

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NINGBO INNO PHARMCHEM CO.,LTD. was established in 2007. It is committed to the R&D, production and sales of raw materials, pharmaceutical intermediates and fine chemicals. We striving to create a high-efficiency and high-quality integrated chemical service platform to better serve domestic and foreign customers.

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