3,5-Bis(trifluoromethyl)phenyl isothiocyanate, identified by its CAS number 23165-29-9, is a highly valuable chemical compound renowned for its critical role in advanced organic synthesis. This fluorinated aromatic isothiocyanate serves as a versatile building block, enabling the creation of complex molecules across various chemical industries. Its unique structural features, including two trifluoromethyl groups and an isothiocyanate functionality, contribute to its distinct reactivity and broad utility.

Known by several synonyms such as 1-isothiocyanato-3,5-bis(trifluoromethyl)benzene and 3,5-Di(trifluoromethyl)phenyl isothiocyanate, this compound possesses a molecular formula of C9H3F6NS and a molecular weight of 271.182. Its physical characteristics are crucial for handling and application. It typically appears as a colorless to pale yellow transparent liquid. Key physical properties include a density of 1.4±0.1 g/cm3, a melting point of 160ºC, and a boiling point of 227.5±40.0 °C at 760 mmHg. The flash point is noted at 91.4±27.3 °C, indicating specific safety considerations for storage and handling.

The primary application of 3,5-Bis(trifluoromethyl)phenyl isothiocyanate lies in its function as an intermediate in organic synthesis. Its reactivity makes it indispensable for a multitude of sophisticated chemical reactions. For instance, it is widely utilized in the chemical derivatization of amino-functionalized model surfaces, including amino thiolate on gold, amino siloxane on silicon, and polyethylene foils and films. This property is vital for surface modification and material science applications. Furthermore, it plays a significant role in the derivatization of self-assembled monolayers of ω-amino-4,4′-terphenyl substituted alkanethiols, opening avenues for advanced material design.

Beyond surface chemistry, 3,5-Bis(trifluoromethyl)phenyl isothiocyanate is instrumental in the synthesis of novel organic compounds. It is a key reagent in the preparation of ethylene-linked sulfonimidoyl-containing thioureas, compounds often explored for their diverse pharmacological properties or as components in new synthetic pathways. Its involvement extends to the preparation of complex amides, such as pyrrolidine-2-carboxylic acid-{2-[3-(3,5-bistrifluoromethylphenyl)thioureido]phenyl}-amide, highlighting its versatility in creating intricate molecular structures. The inclusion of trifluoromethyl groups imparts unique electronic and steric properties, making the resulting derivatives highly stable and often enhancing their biological activity or solubility.

Maintaining high purity is paramount for such a critical synthesis intermediate. Our product, 3,5-Bis(trifluoromethyl)phenyl isothiocyanate, meets stringent specifications with an assay of ≥99.0%. This high level of purity ensures optimal performance and reliability in sensitive chemical reactions, minimizing impurities that could affect downstream processes or final product quality. For packaging, standard provisions include 200 kg/drum, with flexibility to accommodate customer-specific requirements, ensuring convenient and safe transport.

Proper storage is essential to preserve the integrity and efficacy of this valuable compound; it should be stored in a cool, ventilated place, away from incompatible materials. As a dedicated manufacturer and reliable supplier of this specialized chemical, we are committed to providing a consistent and high-quality product. We understand the importance of a stable supply chain for our clients' operational needs. For those looking to buy or purchase 3,5-Bis(trifluoromethyl)phenyl isothiocyanate, competitive price points are available, reflecting our commitment to value without compromising on quality or service. We strive to be a preferred partner for your advanced chemical intermediate needs, ensuring that you receive a premium product supported by exceptional service.