3,5-Pyridinedicarboxylic acid, also widely known as Dinicotinic acid or Pyridine-3,5-dicarboxylic acid, with CAS Number 499-81-0, stands as a highly significant compound in the chemical industry. This organic compound, characterized by its molecular formula C7H5NO4 and a molecular weight of 167.12, plays a pivotal role in numerous synthesis pathways. Its distinct chemical structure, featuring a pyridine ring with two carboxylic acid groups, imbues it with unique reactivity and versatility.

Typically appearing as an off-white to light brown crystalline powder, 3,5-Pyridinedicarboxylic acid exhibits specific physical and chemical properties crucial for its industrial applications. It has a high melting point, generally exceeding 300°C (often cited as 324°C), and a density of approximately 1.52 g/cm³. While it is noted to be sparingly soluble in water (around 1.0g/L), it demonstrates solubility in various organic solvents and alkaline solutions, which is advantageous for diverse synthetic processes.

The primary applications of 3,5-Pyridinedicarboxylic acid are rooted in its utility as a fundamental raw material for organic synthesis and, more notably, as a crucial pharmaceutical intermediate. In the realm of pharmaceuticals, it serves as a building block for the synthesis of complex drug molecules. For instance, research indicates its involvement in the preparation of important pharmaceutical compounds such as Benidipine and Nicardipine, highlighting its contribution to drug development. Beyond its structural role, 3,5-Pyridinedicarboxylic acid is recognized for its biological activity as a competitive inhibitor of butyrobetaine hydroxylase (BBOX1). This enzymatic inhibition mechanism underscores its potential in targeted therapeutic research and development.

Quality assurance is paramount for 3,5-Pyridinedicarboxylic acid, especially given its role in pharmaceutical applications. Reputable manufacturers ensure a purity level typically at or above 98.0%, with some suppliers offering grades up to 99% or higher. Strict quality control measures, including rigorous testing for water content and other impurities, are essential to guarantee the compound's integrity and performance. Proper storage conditions are also vital; the product should be stored in a clean, dry, and cool environment, diligently protected from direct sunlight and moisture to maintain its stability and efficacy over time. Standard packaging often involves 25kg fiber drums, though custom packaging options are available to meet specific customer requirements.

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