3-Bromo-1H-pyrazolo[3,4-d]pyrimidin-4-amine, identified by its CAS number 83255-86-1, stands as a highly significant chemical intermediate in the realm of advanced organic synthesis. This versatile compound, also known by synonyms such as 4-Amino-3-bromo-1H-pyrazolo[3,4-d]pyrimidine, plays a pivotal role in the development of numerous complex molecules, particularly within the pharmaceutical industry. Its unique heterocyclic amine structure, featuring a pyrazolo-pyrimidine core with a distinctive bromine substitution, provides a powerful building block for researchers and chemists aiming to synthesize novel and effective therapeutic agents.

Understanding the physical and chemical characteristics of 3-Bromo-1H-pyrazolo[3,4-d]pyrimidin-4-amine is crucial for its precise application. It typically appears as a white to light yellow crystalline powder, indicating its high purity and consistent quality. Key physical properties include a melting point of approximately 350°C, a density of 2.1±0.1 g/cm³, and a boiling point of 480.6±40.0 °C at 760 mmHg. The compound’s molecular formula is C5H4BrN5, with a molecular weight of 214.023 g/mol. Its flash point is recorded at 244.5±27.3 °C, with a vapor pressure of 0.0±1.2 mmHg at 25°C, and an index of refraction of 1.851. These precise specifications, including an assay of ≥97.0% purity, ensure its reliability for demanding applications.

The primary application of 3-Bromo-1H-pyrazolo[3,4-d]pyrimidin-4-amine lies in pharmaceutical development. It is a critical intermediate in the synthesis of various active pharmaceutical ingredients (APIs). Notably, it serves as an essential precursor for Ibrutinib (CAS: 936563-96-1), a groundbreaking medication used in the treatment of certain cancers, including mantle cell lymphoma and chronic lymphocytic leukemia. Its unique structure enables the precise modifications required to enhance drug efficacy and specificity. Beyond Ibrutinib, researchers are actively exploring its potential in developing other anti-cancer and anti-inflammatory drugs, as well as compounds with promising activity in the field of neuropharmacology. Its ability to interact with various biological targets underscores its significance in medicinal chemistry and innovative drug discovery.

Furthermore, 3-Bromo-1H-pyrazolo[3,4-d]pyrimidin-4-amine extends its utility to a broader spectrum of research and industrial sectors. In biochemical research, it is employed to study enzyme inhibition and receptor interactions, providing invaluable insights into cellular mechanisms and potential therapeutic pathways. Its properties also find relevance in agricultural chemistry, where it is being investigated as a potential component for novel herbicides or fungicides, contributing to improved crop yields and enhanced pest resistance. The compound is also explored within material science for its potential in creating new materials, such as advanced polymers and specialized coatings, which could offer enhanced durability and performance in diverse applications. Moreover, its use in diagnostic tools is under investigation, particularly for developing assays that can detect specific biomarkers, thereby aiding in disease diagnosis and monitoring.

NINGBO INNO PHARMCHEM CO.,LTD. is committed to providing high-quality 3-Bromo-1H-pyrazolo[3,4-d]pyrimidin-4-amine, ensuring it meets stringent industry standards for purity and consistency. Our product is carefully packed in 25 kg/drum, with flexible packaging options available to meet specific customer requirements, and should be stored in a cool, ventilated place to maintain its integrity. As a trusted manufacturer and supplier, we offer this essential chemical intermediate for various research and industrial needs. For those looking to buy or purchase this compound, detailed inquiries regarding the price and availability are welcome. We ensure a reliable supply chain, supporting your projects with high-grade materials and exceptional service.