Understanding the fundamental chemical properties and efficient synthesis routes of key intermediates is vital for any chemical manufacturer. 3-Bromo-2-methoxypyridine, bearing the CAS number 13472-59-8, is a significant player in this domain, serving as a versatile building block for a multitude of organic synthesis applications. As a trusted supplier and manufacturer, we aim to provide clarity on this compound's characteristics and how it can be reliably produced.

Physically, 3-Bromo-2-methoxypyridine is described as a colorless liquid. Its molecular formula is C6H6BrNO, with a molecular weight of 188.02200. Key physical properties include a density of 1.5856, a boiling point of 190.4°C, and a flash point of 93°C. These attributes are important for manufacturers when considering handling, storage, and reaction conditions. For instance, its flash point indicates moderate flammability, requiring standard safety precautions in industrial settings. Researchers often look to buy this compound for its predictable behavior in synthesis.

The synthesis of 3-Bromo-2-methoxypyridine is a topic of considerable interest for chemical companies aiming to produce it efficiently. One common strategy involves the electrophilic bromination of 2-methoxypyridine. However, regioselectivity can be a challenge, with the para position (C-5) often being more reactive due to the activating effect of the methoxy group. To achieve high yields of the desired 3-bromo isomer, optimized conditions, including specific brominating agents like N-bromosuccinimide (NBS) and controlled reaction temperatures, are employed. We continually refine our manufacturing processes to ensure optimal yield and purity.

An alternative and highly effective route involves the O-alkylation of 3-bromo-2-pyridone. This method offers excellent regioselectivity and bypasses the challenges associated with direct bromination. Starting from 3-bromo-2-pyridone, methylation with reagents like methyl iodide in the presence of a base, such as silver carbonate, can yield the target compound with high efficiency. The precise control over these synthetic pathways is what allows us to guarantee a purity of ≥99.0% for the 3-Bromo-2-methoxypyridine we supply.

The importance of this intermediate stems from its utility in various downstream applications, particularly in the synthesis of pharmaceuticals and agrochemicals. Its reactive bromine atom serves as a handle for cross-coupling reactions, allowing for the introduction of diverse functional groups. Chemical companies looking to purchase bulk quantities of reliable intermediates often inquire about its price and availability from manufacturers in China. We are committed to providing high-quality 3-Bromo-2-methoxypyridine to meet these industrial demands.

In conclusion, understanding the chemical properties and efficient synthesis routes of 3-Bromo-2-methoxypyridine is crucial for its industrial application. As a leading manufacturer, we ensure that our product meets the highest standards of purity and consistency, making it an ideal choice for your synthetic needs. We invite you to explore our offerings and consider us your trusted supplier for this vital chemical intermediate.