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3-Iodo-2-methoxypyridine: A Versatile Building Block for Heterocyclic Synthesis

Heterocyclic compounds, molecules containing ring structures with at least one atom other than carbon, are fundamental to numerous fields, including pharmaceuticals, agrochemicals, and material science. The pyridine moiety, in particular, is a ubiquitous feature in many biologically active and functionally important molecules. 3-Iodo-2-methoxypyridine, identified by its CAS number 112197-15-6, serves as an exceptionally versatile building block for the synthesis of a wide array of pyridine-based heterocycles. NINGBO INNO PHARMCHEM CO.,LTD. provides this key intermediate to facilitate the creation of these valuable compounds.

The strategic placement of the iodine atom at the 3-position and the methoxy group at the 2-position of the pyridine ring in 3-iodo-2-methoxypyridine offers multiple avenues for synthetic manipulation. The iodine atom is highly amenable to palladium-catalyzed cross-coupling reactions, allowing for the introduction of various substituents, such as aryl, vinyl, or alkyl groups. This enables chemists to efficiently assemble complex bicyclic or polycyclic heterocyclic systems. For example, a Suzuki coupling with a suitable boronic ester can lead to the formation of biaryl systems, which are common structural motifs in many pharmaceuticals. The ability to perform these transformations at a reasonable price point is critical for the economic viability of many chemical processes.

Furthermore, the methoxy group can be manipulated through demethylation or other reactions, providing additional points for functionalization. The inherent electronic properties of the pyridine ring, modulated by these substituents, also influence its reactivity in electrophilic or nucleophilic aromatic substitution reactions. Researchers can leverage these characteristics to introduce other functional groups or to direct subsequent reactions with high regioselectivity. The importance of a reliable supplier for such a versatile intermediate cannot be overstated, as it directly impacts the success and efficiency of the intended application.

NINGBO INNO PHARMCHEM CO.,LTD. is dedicated to supplying high-purity 3-iodo-2-methoxypyridine, ensuring that chemists have access to a dependable building block for their heterocyclic synthesis projects. Whether the goal is to develop new pharmaceuticals, advanced agrochemicals, or novel materials, the versatility of this pyridine derivative makes it an indispensable tool. For those seeking to buy this compound, partnering with a reputable manufacturer like us guarantees the quality and consistency needed to achieve precise synthetic outcomes, ultimately accelerating innovation across chemical disciplines.

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NINGBO INNO PHARMCHEM CO.,LTD. was established in 2007. It is committed to the R&D, production and sales of raw materials, pharmaceutical intermediates and fine chemicals. We striving to create a high-efficiency and high-quality integrated chemical service platform to better serve domestic and foreign customers.

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2. Own R&D laboratory, pilot platform and large-scale production workshop, which can meet the audit requirements of global customers;

3. We can satisfy customers' perfect transition from small scale lab requirements (gram level) to commercialization requirements (hundred tons level).

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  • A: We don't have Minimum Order Quantity, exact quantity should be provided before quotation for us to calculate the exact cost.

  • A: We don't provide free samples due to lots of request and expensive international courier's cost, we can deduct the sample charge after commercial order placed.

  • A: Our payment terms: Small or sample order: T/T IN ADVANCE. Commercial order: First order should be by T/T IN ADVANCE or L/C at sight, and following orders T/T 30~90days is acceptable subject to approval of credit application.

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