4-(4-Bromo-3-(hydroxymethyl)phenoxy)benzonitrile: A Critical Intermediate for Advanced Pharmaceutical Synthesis

In the dynamic landscape of pharmaceutical manufacturing, the availability of high-quality intermediates is paramount to the successful development and production of life-changing medications. Among these crucial compounds, 4-(4-Bromo-3-(hydroxymethyl)phenoxy)benzonitrile, identified by its CAS number 906673-45-8, stands out as a particularly significant organic building block. This chemical intermediate, with its precise molecular structure (C14H10BrNO2) and a molecular weight of 304.14, serves as a cornerstone in the synthesis of innovative therapeutic agents.

One of its most prominent applications lies in the synthesis of Crisaborole, an active pharmaceutical ingredient (API) widely recognized for its efficacy in treating mild-to-moderate atopic dermatitis, commonly known as eczema. Crisaborole functions as a non-steroidal topical phosphodiesterase-4 (PDE4) inhibitor, offering a valuable alternative for patients seeking effective management of this chronic inflammatory skin condition. The meticulous synthesis of Crisaborole relies heavily on the consistent quality and purity, typically a minimum of 98%, of 4-(4-Bromo-3-(hydroxymethyl)phenoxy)benzonitrile. Its reliable supply is therefore essential for pharmaceutical companies committed to bringing such vital medications to market.

Beyond its indispensable role in Crisaborole production, 4-(4-Bromo-3-(hydroxymethyl)phenoxy)benzonitrile is also highly valued across various other chemical and pharmaceutical research and development efforts. Its unique structural features make it a versatile organic building block for synthesizing a wide array of complex molecules. Researchers and chemists utilize this compound in intricate multi-step syntheses, contributing to advancements in medicinal chemistry, drug discovery, and the creation of novel compounds with potential therapeutic applications. Its stability, with recommended storage under desiccated conditions at room temperature, further enhances its utility and extends its shelf life for research and industrial applications.

As a leading chemical supplier dedicated to supporting global pharmaceutical innovation, we recognize the critical importance of providing intermediates that meet the most stringent quality standards. Our commitment extends to ensuring the purity and consistency of compounds like 4-(4-Bromo-3-(hydroxymethyl)phenoxy)benzonitrile. We adhere to rigorous quality control protocols throughout the manufacturing process, from raw material sourcing to final product packaging, guaranteeing that each batch delivers exceptional performance for its intended application. This dedication helps our partners accelerate their research timelines and streamline their production processes.

For pharmaceutical companies, research institutions, and fine chemical manufacturers looking to procure this vital intermediate, reliable sourcing is key. We pride ourselves on being a trusted supplier and manufacturer of 4-(4-Bromo-3-(hydroxymethyl)phenoxy)benzonitrile, offering competitive prices and efficient global distribution. Whether you need to buy for large-scale production or purchase smaller quantities for research, our dedicated team is ready to assist. We focus exclusively on professional manufacturing, research laboratories, and industrial or commercial usage, ensuring that our products are supplied responsibly and appropriately for their intended advanced chemical synthesis applications.