In the expansive realm of pharmaceutical manufacturing, certain chemical compounds stand out due to their pivotal role in the synthesis of essential medicines. Among these is 4-Amino-6-chlorobenzene-1,3-disulfonamide, a compound with the CAS Registry Number 121-30-2. Also widely recognized by its synonyms such as 5-Chloro-2,4-disulfamoylaniline or Chloraminophenamide, this substance is an indispensable intermediate, particularly in the production of diuretic drugs like Hydrochlorothiazide.

The chemical identity of 4-Amino-6-chlorobenzene-1,3-disulfonamide is defined by its molecular formula, C6H8ClN3O4S2, yielding a molecular weight of 285.73. Its physical characteristics are equally important for its handling and application. It typically presents as a white to off-white crystalline powder, ensuring ease of processing in various industrial settings. Key physical and chemical properties include a melting point ranging from 257-261 °C, a boiling point of approximately 614.4 ± 65.0 °C at 760 mmHg, and a density of 1.8 ± 0.1 g/cm3. These stable properties underscore its reliability as a raw material for complex syntheses.

The primary application of 4-Amino-6-chlorobenzene-1,3-disulfonamide lies in its function as a crucial intermediate for Hydrochlorothiazide. Hydrochlorothiazide is a widely used thiazide diuretic, essential for treating hypertension and edema caused by various conditions. The synthesis pathway often involves the treatment of the corresponding chloride with ammonia in tert-butanol, followed by concentration. A critical step involves its condensation with formic acid, leading to the formation of 6-chloro-7-sulfamoyl-1,2,4-benzothiadiazine 1,1-dioxide, a direct precursor to the final diuretic compound. Beyond its role in Hydrochlorothiazide synthesis, this compound also finds utility as a pharmaceutical secondary standard for quality control, providing laboratories and manufacturers with a reliable benchmark for in-house working standards.

Ensuring the purity and quality of such a vital intermediate is paramount for the efficacy and safety of the final pharmaceutical product. Reputable manufacturers adhere to stringent quality control measures. Typical specifications for 4-Amino-6-chlorobenzene-1,3-disulfonamide include an assay (HPLC) of ≥98.0% and a loss on drying of ≤1.0%. These rigorous standards guarantee that the product meets the exacting requirements of the pharmaceutical industry. Proper storage is also essential to maintain its integrity; it should be stored in a cool, ventilated place, often at temperatures between 2-8°C, to preserve its stability and reactivity over time.

For those seeking a dependable supplier of this essential chemical, various packaging options are available, commonly in 25 kg drums, with flexibility for custom packaging based on customer requirements. When considering the price and availability, it is advisable to engage directly with established manufacturers or distributors to secure competitive rates and ensure consistent supply. Whether you are looking to buy large quantities for pharmaceutical production or purchase smaller amounts for research and development, a reliable partner can provide not only the product but also the necessary technical support and documentation.

In conclusion, 4-Amino-6-chlorobenzene-1,3-disulfonamide (CAS: 121-30-2) remains a cornerstone in the synthesis of critical diuretic medications. Its well-defined chemical and physical properties, coupled with its indispensable role as an intermediate, make it a high-demand compound. Partnering with a trusted supplier is key to leveraging its full potential in pharmaceutical development and production.