In the dynamic landscape of chemical research and synthesis, having access to high-quality, versatile intermediates is fundamental. 4-Bromo-2,3,5,6-tetrafluoropyridine (CAS 3511-90-8) has emerged as a critical compound, empowering scientists to develop novel molecules with enhanced properties. This article explores its significance, applications, and strategies for procurement, particularly when looking to buy from leading manufacturers.

The Chemical Profile of a Versatile Intermediate

4-Bromo-2,3,5,6-tetrafluoropyridine is a member of the highly functionalized heterocyclic compound family. Its molecular structure, C5BrF4N, features a pyridine ring substituted with a bromine atom and four fluorine atoms. This specific arrangement imparts unique reactivity, making it a sought-after building block for advanced organic synthesis. The bromine atom serves as an excellent leaving group for nucleophilic displacement reactions and is readily involved in palladium-catalyzed cross-coupling reactions, such as the Suzuki-Miyaura, Stille, or Sonogashira couplings. The perfluorinated nature of the pyridine ring also influences the electronic and steric properties of the resulting molecules, often leading to improved lipophilicity, metabolic stability, and enhanced biological activity in pharmaceutical or agrochemical applications.

Key Applications Driving Research Forward

The primary utility of 4-Bromo-2,3,5,6-tetrafluoropyridine lies in its role as a pivotal intermediate in the synthesis of complex organic compounds. Researchers employ it extensively for:

• Preparation of Organometallic Reagents: It is crucial for synthesizing organocadmium and organozinc reagents, such as 2,3,5,6-tetrafluoro-pyridylcadmium and 2,3,5,6-tetrafluoropyridylzinc. These reagents are indispensable in modern cross-coupling methodologies.
• Building Block for Fluorinated Molecules: It allows for the facile introduction of the tetrafluoropyridine moiety into larger molecular structures. This is particularly valuable in medicinal chemistry and materials science where fluorine substitution can confer desirable properties.
• Development of Novel Agrochemicals and Pharmaceuticals: The unique electronic and pharmacokinetic properties imparted by the fluorinated pyridine ring make it a target for drug discovery and the development of advanced crop protection agents.

With a typical purity of 97% or higher, and supplied as a clear, colorless liquid, it is well-suited for various laboratory procedures.

Strategic Sourcing: Finding Value from China

For research institutions and chemical companies looking to buy 4-Bromo-2,3,5,6-tetrafluoropyridine, sourcing from reputable Chinese manufacturers offers significant advantages. China has become a global leader in fine chemical production, known for its competitive pricing and high-quality standards. When procuring this intermediate, focusing on manufacturers who can provide a certificate of analysis detailing purity and other specifications is essential. Competitive pricing for this compound, especially when purchased in larger quantities, makes it an accessible option for many R&D budgets. Many Chinese suppliers offer direct sales, allowing for better price negotiation and direct communication regarding product needs. Therefore, when you search to buy this vital chemical, prioritizing suppliers with a proven track record and transparent pricing policies is recommended.

Ensuring Quality and Reliability in Your Supply Chain

The integrity of your research depends on the quality of your starting materials. By choosing to buy 4-Bromo-2,3,5,6-tetrafluoropyridine from established Chinese manufacturers, you gain access to advanced synthesis capabilities and rigorous quality control. This ensures that the compound meets the high purity standards required for sensitive chemical research. A reliable supply chain, backed by responsive customer service, is also critical for project continuity. As you plan your next synthesis, consider the strategic benefits of sourcing this essential research chemical from a trusted Chinese supplier.

In essence, 4-Bromo-2,3,5,6-tetrafluoropyridine is a powerful tool for chemical innovation. Its versatile reactivity and the beneficial properties it can impart make it a cornerstone intermediate for researchers aiming to create groundbreaking molecules.