In the intricate world of pharmaceutical manufacturing, the quality and availability of raw materials and intermediates are foundational to producing safe and effective medicines. 4-Hydrazinobenzenesulfonamide, identified by its CAS number 4392-54-5, stands out as a pivotal intermediate, predominantly utilized in the synthesis of the widely known anti-inflammatory drug, Celecoxib. For R&D scientists, formulators, and procurement professionals, understanding this chemical's properties and its role in the supply chain is crucial for successful operations.

Chemical Profile and Specifications

4-Hydrazinobenzenesulfonamide is characterized by its off-white to light beige powder appearance. Its molecular formula is C6H9N3O2S, with a molecular weight of 187.22 g/mol. A key specification for this intermediate is its assay, which typically meets or exceeds 98.0%. This high purity is essential as it directly influences the efficiency of subsequent synthetic steps and the final purity of the API. The compound's melting point is generally reported between 158-159°C.

Primary Application: Celecoxib Synthesis

The most significant application of 4-Hydrazinobenzenesulfonamide is its use as a key precursor in the manufacturing process of Celecoxib. Celecoxib is a selective COX-2 inhibitor, widely prescribed for treating pain and inflammation associated with conditions like arthritis. The synthesis of Celecoxib involves complex organic reactions where 4-Hydrazinobenzenesulfonamide provides a critical structural component. Manufacturers seeking to produce Celecoxib rely on a consistent and high-quality supply of this intermediate. If you are looking to purchase this compound for your Celecoxib production, it's vital to partner with a reliable manufacturer.

Supplier Landscape and Market Availability

The market for 4-Hydrazinobenzenesulfonamide is supported by numerous chemical suppliers, with a significant concentration of manufacturers based in China. These suppliers offer various packaging options, commonly 25 kg drums, to cater to different industrial needs. When evaluating suppliers, consider their experience, production capacity, quality control measures, and ability to provide necessary documentation. Procurement managers often seek suppliers who can offer competitive prices for bulk purchases while maintaining stringent quality standards. For those looking to buy 4-Hydrazinobenzenesulfonamide, exploring options from reputable manufacturers ensures both cost-effectiveness and product reliability.

Storage and Handling Recommendations

Proper storage is essential to maintain the integrity of 4-Hydrazinobenzenesulfonamide. It should be stored in a cool, well-ventilated place to prevent degradation. Adhering to recommended handling procedures is also important for safety and to preserve the chemical's properties.

In summary, 4-Hydrazinobenzenesulfonamide (CAS 4392-54-5) is an indispensable chemical intermediate for the pharmaceutical industry, particularly for the production of Celecoxib. Its precise specifications and reliable sourcing from experienced manufacturers are key to successful drug manufacturing. Procurement professionals and R&D scientists can leverage the global supply chain to find high-quality material at competitive prices by inquiring with trusted suppliers.