The pharmaceutical industry relies heavily on a consistent supply of high-quality chemical intermediates for the development and manufacturing of life-saving drugs. Among these crucial compounds is 4-Nitro-3-(trifluoromethyl)aniline (CAS: 393-11-3), a versatile molecule that plays a significant role in API synthesis and broader organic chemistry applications. This article delves into its properties, applications, and the importance of partnering with dependable manufacturers.

The Chemical Profile of 4-Nitro-3-(trifluoromethyl)aniline

Chemically known as 4-Nitro-3-(trifluoromethyl)aniline, this compound is typically supplied as a powder with a purity of approximately 97%. Its molecular formula is C7H5F3N2O2, and its molecular weight is 206.12 g/mol. Key physical properties include a melting point range of 125-129 °C and a boiling point of 326.4±42.0 °C. The presence of the trifluoromethyl and nitro groups on the aniline backbone makes it a reactive and useful synthon for introducing these functionalities into more complex molecular structures. Its limited solubility in polar solvents like DMSO and methanol is also a noteworthy characteristic for chemists.

Critical Role in Pharmaceutical Manufacturing

One of the primary applications for 4-Nitro-3-(trifluoromethyl)aniline is its use as a pharmaceutical intermediate. It is a known metabolite of Flutamide, a drug used in the treatment of prostate cancer. This direct link to a vital therapeutic agent highlights the compound's importance in the pharmaceutical supply chain. Researchers and manufacturers developing or producing Flutamide, or similar compounds, require a reliable source of this intermediate to ensure product integrity and efficacy. When you buy 4-Nitro-3-(trifluoromethyl)aniline for these purposes, ensuring its quality and consistent supply is paramount.

Applications in Organic Synthesis

Beyond its direct pharmaceutical applications, 4-Nitro-3-(trifluoromethyl)aniline is a valuable reagent in general organic synthesis. The electron-withdrawing nature of the trifluoromethyl and nitro groups influences the reactivity of the aromatic ring and the amino group, allowing for a variety of chemical transformations. It can be used in reactions such as reduction of the nitro group to an amine, diazotization, and nucleophilic aromatic substitution, opening pathways to diverse organic molecules. For chemical companies looking to develop new synthetic routes or create novel compounds, having a dependable manufacturer for this intermediate is key.

Finding a Reliable Manufacturer

Securing a consistent supply of 4-Nitro-3-(trifluoromethyl)aniline at a competitive price is essential for businesses. As a leading chemical supplier, NINGBO INNO PHARMCHEM CO.,LTD. specializes in providing high-quality intermediates for the global market. We understand the critical needs of the pharmaceutical and chemical industries and are dedicated to offering products that meet rigorous standards. We encourage R&D scientists and procurement professionals to consider us for their requirements. Contact us today to obtain a quote for 4-Nitro-3-(trifluoromethyl)aniline and learn more about our manufacturing capabilities.