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5-Bromo-2-fluoro-4-methylpyridine: A Key Intermediate for Advanced Synthesis

5-Bromo-2-fluoro-4-methylpyridine, identified by its CAS number 864830-16-0, stands as a crucial chemical compound in the realm of advanced organic synthesis. Also known by its synonym, 5-Bromo-2-fluoro-4-picoline, this versatile intermediate plays an indispensable role in creating complex molecular structures across various chemical industries. Its unique chemical structure, featuring a bromine atom, a fluorine atom, and a methyl group on a pyridine ring, grants it specific reactivity and utility, making it a highly sought-after building block for chemists and researchers worldwide.


Understanding the physical and chemical attributes of 5-Bromo-2-fluoro-4-methylpyridine is essential for its effective application. It possesses a density of approximately 1.6±0.1 g/cm³, indicating a moderately dense liquid. The boiling point is recorded at 208.9±35.0 °C at 760 mmHg, suggesting its relative stability at standard atmospheric pressure. With a molecular formula of C6H5BrFN and a molecular weight of 190.013, its elemental composition is well-defined. Furthermore, its flash point is 80.2±25.9 °C, which is a critical safety parameter, emphasizing the need for proper handling and storage in well-ventilated environments, away from ignition sources.


As a high-quality chemical intermediate, 5-Bromo-2-fluoro-4-methylpyridine typically appears as a colorless to light yellow liquid. Reputable suppliers ensure that the assay, or purity level, is consistently high, generally at 98.0% or greater, to guarantee optimal performance in subsequent reactions. The moisture content is also tightly controlled, typically not exceeding 0.5%, to prevent unwanted side reactions or degradation. Adherence to these stringent specifications is paramount for successful synthetic processes, particularly in sensitive applications where even trace impurities can compromise product integrity and yield.


The primary application of 5-Bromo-2-fluoro-4-methylpyridine lies in its function as an organic synthesis intermediate. Its reactive bromine and fluorine substituents, combined with the pyridine core, make it an invaluable precursor for synthesizing a wide array of fine chemicals, pharmaceuticals, and agrochemicals. It is frequently employed in cross-coupling reactions, such as Suzuki, Sonogashira, or Heck couplings, to introduce new functionalities or extend molecular frameworks. This compound can serve as a key building block in the development of novel drugs, advanced materials, and crop protection agents, contributing significantly to innovation in these critical sectors. Its utility extends to academic research and industrial production alike, facilitating the creation of complex organic molecules.


Proper storage and packaging are vital to maintain the quality and stability of 5-Bromo-2-fluoro-4-methylpyridine. It is commonly supplied in robust containers, such as 200 kg drums, designed to protect the chemical during transit and storage. Customers can also benefit from customized packaging solutions tailored to their specific quantity requirements, ensuring flexibility for various project scales. Storage conditions are straightforward yet crucial: the compound should be kept in a cool, well-ventilated area, shielded from direct sunlight and excessive heat. Adhering to these guidelines helps preserve its purity and reactivity over extended periods, maximizing its shelf life and usability.


When seeking high-quality 5-Bromo-2-fluoro-4-methylpyridine, it is essential to partner with a reliable manufacturer and supplier. NINGBO INNO PHARMCHEM CO.,LTD. stands as a distinguished entity in the chemical industry, offering this indispensable intermediate with assured purity and consistent quality. As a dedicated manufacturer, we understand the critical demand for reliable chemical building blocks in complex synthesis pathways. We maintain rigorous quality control standards throughout the production process to ensure that every batch meets the highest specifications. For those looking to buy or purchase 5-Bromo-2-fluoro-4-methylpyridine, we provide competitive price options and flexible supply solutions, catering to both small-scale research needs and large-volume industrial requirements. Our commitment as a leading supplier ensures prompt delivery and comprehensive technical support, making us the preferred choice for your chemical sourcing needs. Contact us today to inquire about our product availability and how we can support your next innovative project.

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